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http://hdl.handle.net/1843/61673| Type: | Artigo de Periódico |
| Title: | Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery |
| Authors: | Ana Paula de Figueiredo Monteiro Larissa Durães Caminhas José Domingos Ardisson Roberto Magalhães Paniago María Esperanza Cortés Segura Rubén Dario Sinisterra Millán |
| Abstract: | In the present work, we study the role of different components in the formation of more stable iron oxide magnetic nanoparticles (MNPs): β-cyclodextrin (BCD), 2-hydroxypropyl-β-cyclodextrin (HP) and citrate anion. MNPs formulations were characterized by FTIR, particles size measurements, zeta potential based on dynamic light scattering principle technique, X-ray powder pattern diffraction, XPS spectroscopy, transmission electron microscopy and thermogravimetric analysis. The results showed that cyclodextrins and citrate plays a key role in order to obtain a lower size of coated MNPs and proved to be an efficient strategy to obtain a more stable colloidal dispersion, avoiding the nanoparticles oxidation, enhancing the irinotecan incorporation and release. Furthermore, citrate-coated BCD-MNPs showed the same cytotoxicity of the free IRI. |
| Subject: | Ciclodextrinas Nanopartículas Sistemas de distribuição de medicamentos Câncer - Tratamento Potencial zeta Luz - Espalhamento Termogravimetria Microscopia eletrônica - Técnica Raios X - Difração Fourier, Espectroscopia de infravermelho por transformada de |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICX - DEPARTAMENTO DE FÍSICA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.carbpol.2016.11.091 |
| URI: | http://hdl.handle.net/1843/61673 |
| Issue Date: | May-2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0144861716313698 |
| metadata.dc.relation.ispartof: | Carbohydrate Polymers |
| Appears in Collections: | Artigo de Periódico |
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