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http://hdl.handle.net/1843/61688| Type: | Artigo de Periódico |
| Title: | Burkitt lymphoma of the head and neck: an international collaborative study |
| Authors: | Mário José Romañach Lady Paola Aristizabal Arboleda Liam Robinson Willie van Heerden Román Carlos Elena María José Román Tager Iva Loureiro Hoffmann Izilda Aparecida Cardinalli Regina Maria Holanda Mendonça Marianne Vasconcelos Carvalho Allan Vinícius Martins-de-Barros André Caroli Rocha Carla Isabelly Rodrigues-Fernandes Syed Ali Khurram Paul Speight Marcio Ajudarte Lopes Pablo Agustin Vargas Oslei Paes Almeida Alan Roger Santos-Silva Bruno Augusto Linhares Almeida Mariz Bruno Augusto Benevenuto Andrade Aline Corrêa Abrahão Michelle Agostini Hélder Antônio Rebelo Pontes Felipe Paiva Fonseca |
| Abstract: | Background: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma with three variants (endemic, sporadic, and immunodeficiency-associated), presenting with specific epidemiological and clinical features. Burkitt lymphoma affects the head and neck region (BLHN) in approximately 10% of cases. The aim of this study was to undertake a comparative analysis of the clinicopathologic and immunohistochemical (IHC) features of BLHN diagnosed in patients from Africa, Guatemala, and Brazil. Methods: Cases diagnosed as BLHN were collected from the files of six oral pathology laboratory services (Brazil, South Africa, and Guatemala) and one Brazilian pediatric oncology hospital from 1986 to 2020. Clinicopathological and IHC data, and Epstein-Barr virus (EBV) status by in situ hybridization data for each case were reviewed and described. Results: Of the 52 cases, BLHN was predominant in pediatric patients [43 (82.69%)] and males [43 (82.69%)], with a mean age of 11.26 ± 9.68 years (range, 1-39 years). Neck and cervical lymph nodes [14 (26.92%)], and involvement of both maxilla and mandible [8 (15.38%)], were the most common anatomical sites. Clinically, tumor/swelling [40 (31.25%)], cervical lymphadenopathy [14 (10.94%)], pain [12 (9.38%)], and bone destruction [12 (9.38%)] were frequent findings. All cases showed typical morphological characteristics of BL. IHC profiles included positivity for CD20 [52 (100%)], CD10 [38 (79.17%)], Bcl6 [29 (87.88%)], and c-Myc protein [18 (81.82%)]. EBV was positive in 18 cases (62.07%). The Ki-67 index ranged from 90 to 100%. |
| Subject: | Burkitt lymphoma Head Neck Lymphoma, non-Hodgkin Pediatrics Immunohistochemistry |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jop.13209 |
| URI: | http://hdl.handle.net/1843/61688 |
| Issue Date: | 2021 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.13209 |
| metadata.dc.relation.ispartof: | Journal of Oral Pathology & Medicine |
| Appears in Collections: | Artigo de Periódico |
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