Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/61828
Type: Artigo de Periódico
Title: Serological survey for igg antibodies against sars-cov-2 through newborn screening
Other Titles: Inquérito sorológico para anticorpos IgG contra SARS-CoV-2 de recém-nascidos e suas mães
Authors: Vívian Mara Gonçalves de Oliveira Azevedo
Claudia Regina Lindgren Alves
Gabriela Soutto Mayor Assumpção Pinheiro
Aline Almeida Bentes
Gabriela Cintra Januário
José Nélio Januário
Mila Lemos Cintra
Ana Beatriz Araújo de Souza
Laura Gregório Pires
Stela Maris Aguiar Lemos
Abstract: This serological survey, conducted in five Brazilian municipalities, evaluated the use of dried blood spots (DBS), obtained from newborns and their mothers, to detect SARS-CoV-2 IgG antibodies. DBS were obtained from 4,803 neonates aged up to seven days and their mothers, both asymptomatic, at public health care clinics during newborn screening. DBS were processed by ELISA to detect IgG antibodies against SARS-CoV-2 nucleocapsid antigen. Mothers of seropositive neonates were interviewed about sociodemographic char acteristics and clinical and laboratory antecedents. Non-satisfactory samples, dyads with incomplete data, and vaccinated mothers were excluded. Of the 1,917 DBS dyads samples analyzed, 14.7% of neonates showed IgG antibodies against SARS-CoV-2. Among seropositive neonates, 73.2% of their mothers were also seropositive. More than half of the mothers with seropositive neonates denied clinical or laboratory suspicion of COVID-19 during pregnancy. Suspicion occurred in the third trimester for 24.6% of the mothers. This study tested an innovative strategy to improve the understanding of COVID-19 antibody dynamics during pregnancy and suggests the feasibility of a universal serological survey in puerperal women and neonates.
Subject: SARS-CoV-2
Newborn
Pregnancy
Neonatal Screening
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: MED - DEPARTAMENTO DE FONOAUDIOLOGIA
Rights: Acesso Aberto
metadata.dc.identifier.doi: 10.1590/0102-311XEN021022
URI: http://hdl.handle.net/1843/61828
Issue Date: 2022
metadata.dc.url.externa: https://doi.org/10.1590/0102-311XEN021022
metadata.dc.relation.ispartof: Cadernos de Saúde Pública
Appears in Collections:Artigo de Periódico



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