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Type:	Artigo de Periódico
Title:	The COVID-19 pandemic in Brazilian pregnant and postpartum women: results from the REBRACO prospective cohort study
Authors:	Renato T. Souza Silvana F. Bento Bruna E. Parreira José P. Guida Mário Dias Corrêa Júnior Caio Leal Rayra Amana Marcos A. B. Dias Marcos Nakamura-Pereira Bruna O. Guerra Gabriela Gorga Leandro de Oliveira Carla Silveira Kevin F. A. Oliveira Mariana Emi Varicoda Makyama Elias F. Melo Junior Débora F. Leite Isabella Monteiro Marília G. Q. Luz Isabela R. Pereira Clélia Andrade Salustrino Valéria B. Pontes Roberto Allen Silva Franco Fernanda G. Surita João Paolo Bilibio Gislânia P. F. Brito Hana Paula C. Pinto Danielle Leal Oliveira Andrezza A. Guerra Andrea O. Moura Natasha Pantoja Fernanda David Alina Silva Maria J. Miele Ricardo P. Tedesco Karayna G. Fernandes Sérgio H. A. Martins-Costa Frederico J. A. Peret Francisco E. Feitosa Rosiane Mattar Jose G. Cecatti Evelyn Traina Edson V. Cunha Filho Janete Vettorazzi Samira M. Haddad Carla B. Andreucci Rodolfo C. Pacagnella Maria Laura Costa Carolina C. Ribeiro-do-Valle Adriana G. Luz Giuliane J. Lajos Guilherme M. Nobrega Thayna B. Griggrio Charles M. Charles Sherly Metelus Lester Castro Stephanie Pabon Amanda D. Silva Paulo S. R. Junior Thais G. Sardinha Rodolfo R. Japenga Erica R. F. Urquiza Maíra R. Machado Marcela Maria Simões Larissa M. Solda Juliana Vasconcellos Freitas-Jesus Rachel Esteves Soeiro Patrícia B. Peres Cristiane L. Arbeli Rafael M. Quevedo Carolina F. Yamashita Julia D. Corradin Isabella Bergamini José Geraldo L. Ramos Maria Lúcia R. Oppermann Laisa S. Quadro Lina Marins Érika V. Paniz Thaís Vicentini Xavier Marina H. L. Almeida Bruna F. V. Moura Lidiane R. França Hanna Vieira Rafael B. Aquino Thayna B. Griggio Aline C. Costa Daisy Pinheiro Denise Cordeiro Priscila L. Miná Carol Dornellas Sue Yazaki-sun Priscilla Mota Arimaza C. Soares Edson V. Cunha Filho Ellen Machado Anne Bergmann Gustavo Raupp Santos Aline Tosetto Sabrina Savazoni
Abstract:	Brazil presented a very high number of maternal deaths and evident delays in healthcare. We aimed at evaluating the characteristics of SARS-CoV-2 infection and associated outcomes in the obstetric population. We conducted a prospective cohort study in 15 Brazilian centers including symptomatic pregnant or postpartum women with suspected COVID-19 from Feb/2020 to Feb/2021. Women were followed from suspected infection until the end of pregnancy. We analyzed maternal characteristics and pregnancy outcomes associated with confirmed COVID-19 infection and SARS, determining unadjusted risk ratios. In total, 729 symptomatic women with suspected COVID-19 were initially included. Among those investigated for COVID-19, 51.3% (n = 289) were confirmed COVID-19 and 48% (n = 270) were negative. Initially (before May 15th), only 52.9% of the suspected cases were tested and it was the period with the highest proportion of ICU admission and maternal deaths. Non-white ethnicity (RR 1.78 [1.04–3.04]), primary schooling or less (RR 2.16 [1.21–3.87]), being overweight (RR 4.34 [1.04–19.01]) or obese (RR 6.55 [1.57–27.37]), having public prenatal care (RR 2.16 [1.01–4.68]), planned pregnancies (RR 2.09 [1.15–3.78]), onset of infection in postpartum period (RR 6.00 [1.37–26.26]), chronic hypertension (RR 2.15 [1.37–4.10]), pre-existing diabetes (RR 3.20 [1.37–7.46]), asthma (RR 2.22 [1.14–4.34]), and anaemia (RR 3.15 [1.14–8.71]) were associated with higher risk for SARS. The availability of tests and maternal outcomes varied throughout the pandemic period of the study; the beginning was the most challenging period, with worse outcomes. Socially vulnerable, postpartum and previously ill women were more likely to present SARS related to COVID-19.
Subject:	COVID-19 Gravidez Brasil Período Pós-Parto
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	MED - DEPARTAMENTO DE GINECOLOGIA OBSTETRÍCIA MEDICINA - FACULDADE DE MEDICINA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1038/s41598-022-15647-z
URI:	http://hdl.handle.net/1843/61844
Issue Date:	11-Jul-2022
metadata.dc.url.externa:	https://www.nature.com/articles/s41598-022-15647-z
metadata.dc.relation.ispartof:	Scientific Reports
Appears in Collections:	Artigo de Periódico

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