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http://hdl.handle.net/1843/62135| Tipo: | Artigo de Periódico |
| Título: | Iminecalix[4]arenes: microwave-assisted synthesis, x-ray crystal structures, and anticandidal activity |
| Autor(es): | Cleiton Moreira da Silva Danielle Letícia da Silva Thaís Furtado Ferreira Magalhães Rosemeire Brondi Alves Maria Aparecida Resende Stoianoff Felipe Terra Martins Ângelo de Fátima |
| Resumen: | In this study, six iminecalix[4]arenes were synthesized and the crystal structures of two of the iminecalix[4]arenes were also determined. Iminecalix[4]arene adopts a strongly pinched cone conformation with two upper rim substituents pointing toward and the other two pointing away from the aromatic cavity. This uncommon conformation is stabilized by an intramolecular π…π interaction between the phenyl rings from the upper rim substituents pointing inwards the cone. In addition, phenyl rings from the substituent groups are not coplanar with respect to the calixarene phenyl rings holding them. The compounds, as well as their respective monomeric units, were evaluated for their antifungal activities against Candida strains. All the synthesized iminecalix[4]arenes were found to cause higher inhibition of all tested Candida strains than their respective monomers. The ratio between the minimal inhibitory concentration (MIC) of a monomer and the corresponding iminecalix[4]arene ranged from 2.05 to 36.50. Furthermore, the iminecalix[4]arene bearing nitrofuran group exhibited low MIC values comparable to that of fluconazole. Thus, this compound was twice more active than fluconazole against Candida krusei. |
| Asunto: | Calixarenos Antimicóticos Cristalografia de raio X Candida Espectrometria de massa |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1016/j.arabjc.2016.06.013 |
| URI: | http://hdl.handle.net/1843/62135 |
| Fecha del documento: | 2019 |
| metadata.dc.url.externa: | http://www.sciencedirect.com/science/article/pii/S1878535216300910 |
| metadata.dc.relation.ispartof: | Arabian Journal of Chemistry |
| Aparece en las colecciones: | Artigo de Periódico |
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| archivo | Descripción | Tamaño | Formato | |
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| Iminecalix[4]arenes microwave-assisted synthesis, x-ray crystal structures, and anticandidal activity.pdf | 1.49 MB | Adobe PDF | Visualizar/Abrir |
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