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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/62135
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dc.creatorCleiton Moreira da Silvapt_BR
dc.creatorDanielle Letícia da Silvapt_BR
dc.creatorThaís Furtado Ferreira Magalhãespt_BR
dc.creatorRosemeire Brondi Alvespt_BR
dc.creatorMaria Aparecida Resende Stoianoffpt_BR
dc.creatorFelipe Terra Martinspt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.date.accessioned2023-12-22T14:33:20Z-
dc.date.available2023-12-22T14:33:20Z-
dc.date.issued2019-
dc.citation.volume12pt_BR
dc.citation.issue8pt_BR
dc.citation.spage4365pt_BR
dc.citation.epage4376pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.arabjc.2016.06.013pt_BR
dc.identifier.issn1878-5352pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/62135-
dc.description.resumoIn this study, six iminecalix[4]arenes were synthesized and the crystal structures of two of the iminecalix[4]arenes were also determined. Iminecalix[4]arene adopts a strongly pinched cone conformation with two upper rim substituents pointing toward and the other two pointing away from the aromatic cavity. This uncommon conformation is stabilized by an intramolecular π…π interaction between the phenyl rings from the upper rim substituents pointing inwards the cone. In addition, phenyl rings from the substituent groups are not coplanar with respect to the calixarene phenyl rings holding them. The compounds, as well as their respective monomeric units, were evaluated for their antifungal activities against Candida strains. All the synthesized iminecalix[4]arenes were found to cause higher inhibition of all tested Candida strains than their respective monomers. The ratio between the minimal inhibitory concentration (MIC) of a monomer and the corresponding iminecalix[4]arene ranged from 2.05 to 36.50. Furthermore, the iminecalix[4]arene bearing nitrofuran group exhibited low MIC values comparable to that of fluconazole. Thus, this compound was twice more active than fluconazole against Candida krusei.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArabian Journal of Chemistrypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCalix[4]arenept_BR
dc.subjectAldiminept_BR
dc.subjectIminecalix[4]arenes microwave-assisted synthesispt_BR
dc.subjectAntifungal activitypt_BR
dc.subjectX-ray crystal structurept_BR
dc.subjectPinched cone conformationpt_BR
dc.subject.otherCalixarenospt_BR
dc.subject.otherAntimicóticospt_BR
dc.subject.otherCristalografia de raio Xpt_BR
dc.subject.otherCandidapt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.titleIminecalix[4]arenes: microwave-assisted synthesis, x-ray crystal structures, and anticandidal activitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://www.sciencedirect.com/science/article/pii/S1878535216300910pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9913-8971pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1447-6670pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0546-2549pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6220-1321pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
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