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http://hdl.handle.net/1843/62545| Type: | Artigo de Periódico |
| Title: | Vasoactive intestinal peptide degradation might influence interleukin-17 expression in cardiac chagasic patients |
| Authors: | Francielle Beltrãopereira Walderez Ornelas Dutra Kenneth j. Gollob Edna Afonso Reis Ana Laura Grossi de Oliveira Manoel Otávio da Costa Rocha Cristiane Alves da Silva Menezes |
| Abstract: | The vasoactive intestinal peptide (VIP) expression is lower in cardiac chagasic patients and is related to worse cardiac function. The reduction of VIP in patients with Chagas disease may be a result of its enhanced degradation. To test this hypothesis, the tryptase and chymase expression was evaluated. We also related VIP levels with interleukin-17 (IL 17) expression since VIP may modulate IL-17 production. Plasma levels of chymase were higher in chagasic patients. Conversely, VIP/chymase and VIP/tryptase ratios were lower in chagasic patients when compared to non-infected individuals. Besides, the VIP/chymase ratio was lower in chagasic cardiac patients in comparison with the indeterminate group. A positive correlation between tryptase and chymase levels was observed in chagasic cardiac patients. In relation to IL-17, we observed a higher expression of this cytokine in the cardiac form of the disease than in the indeterminate form. IL-17/VIP ratio was higher in the cardiac form in comparison with non-infected or indeterminate form. These results suggest that the low levels of VIP observed in chagasic patients could be due to an increased production of chymase and/or to the additive effect of the interaction between chymase and tryptase in the cardiac form. Moreover, the decreased VIP expression may contribute to the increase of IL-17 in chagasic cardiac patients. |
| Subject: | Chagas disease Tryptases Chymases Vasoactive Intestinal Peptide Interleukin-17 |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE MORFOLOGIA ICX - DEPARTAMENTO DE ESTATÍSTICA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1590/s1678-9946201860057 |
| URI: | http://hdl.handle.net/1843/62545 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://www.scielo.br/j/rimtsp/a/TgN6rnJcFxkx6gFndWbK6nB/?lang=en |
| metadata.dc.relation.ispartof: | Revista do Instituto de Medicina Tropical de São Paulo |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Vasoactive intestinal peptide degradation might influence pdfa.pdf | 635.71 kB | Adobe PDF | View/Open |
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