Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/63156
Tipo: Artigo de Periódico
Título: The influence of splenic tissue on the survival and tcd4 and tcd8 lymphocyte rates in rats subjected to fecal peritonitis induction
Autor(es): Andrea Saade Daher Borjaili
Danilo Nagib Salomão Paulo
Tarcizo Afonso Nunes
Giseli Celestino Nunes
Julia Belizário Silveira
Flávia Heiderich Dall'orto
Gabriel Souza Lorenzoni
Matheus Eduardo Daher Borjaili
Bianca Prandi Campagnaro
Maressa Cristiane Malini de Lima
Marcela Souza Lima Paulo
Resumo: Purpose: Comparing survival rates of rats subjected to spleen procedures after fecal peritonitis induction. Assessing changes in TCD4 and CD8 lymphocyte rates before and after the procedures. Correlating animal survival with CD4 and CD8 lymphocytes. Methods: Thirty male Wistar rats were distributed into 3 groups of ten: spleen manipulation (SM); total splenectomy (TS); subtotal splenectomy with preservation of the inferior pole (IP). Rats were subjected to surgical procedure depending on the group. Seven days after surgery they underwent induction of peritonitis and survival time was recorded. All animals were subjected to two blood collections: before surgery and 70 days after it for TCD4/TCD8 lymphocyte counting. Results: Mean survival time was longer in the IP and SM groups and shorter in the TS group; there was significant difference between them. The comparison of the median number of CD4 did not present changes, whereas the comparison of the median number of CD8 decreased in the SM and IP groups. The correlation between the median number of TCD4 and TCD8 lymphocytes and the animals’ survival was not significant. Conclusion: The maintenance of splenic tissue contributed to increase the survival of rats and there was a change in the number of TCD8 lymphocytes
Assunto: Splenectomy
Peritonitis
Spleen
Immunophenotyping
Survival Rate
Rats
Idioma: eng
País: Brasil
Editor: Universidade Federal de Minas Gerais
Sigla da Instituição: UFMG
Departamento: MED - DEPARTAMENTO DE CIRURGIA
Tipo de Acesso: Acesso Aberto
Identificador DOI: https://doi.org/10.1590/s0102-865020200100000003
URI: http://hdl.handle.net/1843/63156
Data do documento: 2020
metadata.dc.url.externa: https://doi.org/10.1590/s0102-865020200100000003
metadata.dc.relation.ispartof: Acta Cirúrgica Brasileira
Aparece nas coleções:Artigo de Periódico

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