1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63162
Full metadata record
DC FieldValueLanguage
dc.creatorMohit Sharmapt_BR
dc.creatorFelipe Paiva Fonsecapt_BR
dc.creatorKeith Hunterpt_BR
dc.creatorRaghu Radhakrishnanpt_BR
dc.date.accessioned2024-01-19T19:08:21Z-
dc.date.available2024-01-19T19:08:21Z-
dc.date.issued2020-08-21-
dc.citation.volume12pt_BR
dc.citation.issue1pt_BR
dc.citation.spage23pt_BR
dc.citation.epagespt_BR
dc.identifier.doihttps://doi.org/10.1038/s41368-020-00090-5pt_BR
dc.identifier.issn16742818pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63162-
dc.description.resumoThe integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational journal of oral sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLoss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation fao clinica open acess assunto células tronco e Oral Submucous Fibrosis busca dia 26 do 10 2023pt_BR
dc.subject.otherStem cellspt_BR
dc.subject.otherOral submucous fibrosispt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherProteinspt_BR
dc.subject.otherBiomarkerspt_BR
dc.subject.otherMoloney murine leukemia viruspt_BR
dc.subject.otherAldehyde dehydrogenase 1 familypt_BR
dc.subject.otherDown-regulationpt_BR
dc.subject.otherUp-regulationpt_BR
dc.titleLoss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.nature.com/articles/s41368-020-00090-5pt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation.pdf2 MBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.