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http://hdl.handle.net/1843/63162| Type: | Artigo de Periódico |
| Title: | Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation |
| Authors: | Mohit Sharma Felipe Paiva Fonseca Keith Hunter Raghu Radhakrishnan |
| Abstract: | The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review. |
| Subject: | Stem cells Oral submucous fibrosis Carcinoma, squamous cell Neoplasms Proteins Biomarkers Moloney murine leukemia virus Aldehyde dehydrogenase 1 family Down-regulation Up-regulation |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1038/s41368-020-00090-5 |
| URI: | http://hdl.handle.net/1843/63162 |
| Issue Date: | 21-Aug-2020 |
| metadata.dc.url.externa: | https://www.nature.com/articles/s41368-020-00090-5 |
| metadata.dc.relation.ispartof: | International journal of oral science |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation.pdf | 2 MB | Adobe PDF | View/Open |
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