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http://hdl.handle.net/1843/63431| Type: | Artigo de Periódico |
| Title: | Versatile grafted microcrystalline cellulose with ionic liquid as new Losartan-controlled release material |
| Authors: | Stefânia Sales de Oliveira Santos Rubén Dario Sinisterra Millán Marcelo Gomes Speziali |
| Abstract: | This paper describes the preparation and characterization of a versatile Losartan-controlled-release material based on a functionalized cellulosic matrix grafted with the ionic liquid, [(MeO)3Sipmim][Cl]: 1–(trimethoxysilylpropyl)–3–methylimidazolium Chloride. A silanized ionic liquid was used as a solvent and a surface modification agent at the same time, allowing higher anionic drug loading capacity. The anionic Losartan drug release kinetics were evaluated as a model. The Losartan release was made using two distinct media, one at pH 7.4 and the other at 3.0 to simulate blood and stomach pH, respectively. Higher Losartan release-rate 88% at blood pH after 1085 min in comparison with 84% at stomach pH, after 330 min was attained. The higher Losartan release profile in acid pH compared with neutral pH could be associated to the hydrolysis of Si-O bond from the ionic liquid, with the acidic medium acting as a catalyst. This cellulosic matrix modified with ionic liquid showed promising for applications over a wide range of pH-controlled-release systems. |
| Subject: | Química Tecnologia de liberação controlada Agentes hipotensores Cinética quimica Química de superfície Celulose - Química |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.eurpolymj.2020.109490 |
| URI: | http://hdl.handle.net/1843/63431 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0014305719320543 |
| metadata.dc.relation.ispartof: | European Polymer Journal |
| Appears in Collections: | Artigo de Periódico |
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