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http://hdl.handle.net/1843/63434| Tipo: | Artigo de Periódico |
| Título: | Uniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell line |
| Autor(es): | Diego Fernando Suárez Peñaranda Ana Delia Pinzón García Rubén Dario Sinisterra Millán Anderson Dussan Cuenca Fredy Mesa Sandra Ramírez-Clavijo |
| Resumo: | Breast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is being tested. Both were coupled with nanoscale-controlled and sustained release systems to increase the effectiveness of the treatment and reduce adverse effects. We produced a controlled release system based on uniaxial and coaxial polymeric nanofibers of polycaprolactone (PCL), alginate (Alg) and gelatine (Gel) for the transport and release of TMX and Cur, as a new alternative to breast cancer treatment. Nanofibers combining PCL–Alg and PCL–Gel were fabricated by the electrospinning technique and physicochemically characterised by thermal analysis, absorption spectroscopy in the infrared region and X-ray diffraction. Morphology and size were studied by scanning electron microscopy. Additionally, the release profile of TMX and Cur was obtained by UV-Vis spectroscopy. Additionally, the cytotoxic effect on breast cancer cell line MCF7 and peripheral-blood mononuclear cells (PBMCs) from a healthy donor were evaluated by a Resazurin reduction assay. These assays showed that PCL–TMX nanofiber was highly toxic to both cell types, while PCL–Cur was less toxic. |
| Assunto: | Mamas - Câncer Tecnologia de liberação controlada Agentes antineoplásicos |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.3390/nano12193348 |
| URI: | http://hdl.handle.net/1843/63434 |
| Data do documento: | 2022 |
| metadata.dc.url.externa: | https://www.mdpi.com/2079-4991/12/19/3348 |
| metadata.dc.relation.ispartof: | Nanomaterials |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Uniaxial and coaxial nanofibers pclalginate or pclgelatine transport and release tamoxifen and curcumin affecting the viability of mcf7 cell line.pdf | 2.77 MB | Adobe PDF | Visualizar/Abrir |
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