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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/63434
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dc.creatorDiego Fernando Suárez Peñarandapt_BR
dc.creatorAna Delia Pinzón Garcíapt_BR
dc.creatorRubén Dario Sinisterra Millánpt_BR
dc.creatorAnderson Dussan Cuencapt_BR
dc.creatorFredy Mesapt_BR
dc.creatorSandra Ramírez-Clavijopt_BR
dc.date.accessioned2024-01-26T18:51:46Z-
dc.date.available2024-01-26T18:51:46Z-
dc.date.issued2022-
dc.citation.volume12pt_BR
dc.citation.issue19pt_BR
dc.identifier.doihttps://doi.org/10.3390/nano12193348pt_BR
dc.identifier.issn2079-4991pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/63434-
dc.description.resumoBreast cancer is the second cause of cancer death in women worldwide. The search for therapeutic and preventive alternatives has increased in recent years. One synthetic drug for patients with hormone receptor-positive tumours is tamoxifen citrate (TMX). Curcumin (Cur) is a natural compound that is being tested. Both were coupled with nanoscale-controlled and sustained release systems to increase the effectiveness of the treatment and reduce adverse effects. We produced a controlled release system based on uniaxial and coaxial polymeric nanofibers of polycaprolactone (PCL), alginate (Alg) and gelatine (Gel) for the transport and release of TMX and Cur, as a new alternative to breast cancer treatment. Nanofibers combining PCL–Alg and PCL–Gel were fabricated by the electrospinning technique and physicochemically characterised by thermal analysis, absorption spectroscopy in the infrared region and X-ray diffraction. Morphology and size were studied by scanning electron microscopy. Additionally, the release profile of TMX and Cur was obtained by UV-Vis spectroscopy. Additionally, the cytotoxic effect on breast cancer cell line MCF7 and peripheral-blood mononuclear cells (PBMCs) from a healthy donor were evaluated by a Resazurin reduction assay. These assays showed that PCL–TMX nanofiber was highly toxic to both cell types, while PCL–Cur was less toxic.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofNanomaterialspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectNanofiberpt_BR
dc.subjectCurcuminpt_BR
dc.subjectTamoxifenpt_BR
dc.subjectBreast cancerpt_BR
dc.subjectElectrospinningpt_BR
dc.subjectMCF-7pt_BR
dc.subject.otherMamas - Câncerpt_BR
dc.subject.otherTecnologia de liberação controladapt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.titleUniaxial and coaxial nanofibers PCL/alginate or PCL/gelatine transport and release tamoxifen and curcumin affecting the viability of MCF7 cell linept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/2079-4991/12/19/3348pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3139-4239pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8876-4907pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7656-1849pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5355-2640pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0920-7748pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0336-5614pt_BR
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