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http://hdl.handle.net/1843/63455| Type: | Artigo de Periódico |
| Title: | Sulfonamide-functionalized polymeric nanoparticles for enhanced in vivo colorectal cancer therapy |
| Authors: | Pedro Pires Goulart Guimarães Celso Tarso Rodrigues Viana Luciana Xavier Pereira Sávio Morato Lacerda Gontijo Paula Peixoto Campos Silvia Passos Andrade Robson Augusto Souza dos Santos Rubén Dario Sinisterra Millán |
| Abstract: | Background: Colorectal cancer (CRC) is the third most common cancer in the world. 5- Fluorouracil (5-FU) is a conventional and most effective drug used in the clinic for the treatment of CRC. However, the clinical use of 5-FU is limited due to the acquired resistance and systemic toxicity, such as hepatotoxicity and gastrointestinal toxicity. Objective: Recent advances in nanomedicine are being exploited to develop nanoparticle platforms to overcome resistance and therapeutic delivery of active molecules. Here, we developed 5-FU loaded sulfadiazine-poly(lactide-co-glycolide) nanoparticles (SUL-PLGA NPs) to be applied in the colorectal cancer model. Methods: We assessed the in vivo efficacy of the SUL-PLGA NPs to enhance the antitumor effect of 5-FU. Results: In vivo treatment with 5-FU-SUL-PLGA NPs significantly reduced tumor growth in a colon cancer xenograft model compared to free 5-FU and 5-FU loaded non-targeted NPs. Treatment with 5-FU-SUL-PLGA NPs also increased blood vessel diameters within tumors, which could act in conjunction to enhance antitumor efficacy. In addition, 5-FU-SUL-PLGA NPs significantly reduced liver mass and lung mass, which are the most common metastasis sites of CRC, and decreased liver hepatotoxicity compared to free 5-FU drug and 5-FU loaded non-targeted NPs. Conclusion: Our findings suggest that the use of 5-FU-SUL-PLGA NPs is a promising strategy to enhance 5-FU efficacy against CRC. |
| Subject: | Nanopartículas Câncer - Tratamento Cólon (Anatomia) - Câncer Sistema de distribuição de medicamentos Sistemas deliberados de drogas poliméricas Ácidos sulfônicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE PATOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.2174/1567201818666210729110127 |
| URI: | http://hdl.handle.net/1843/63455 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://www.eurekaselect.com/article/116952 |
| metadata.dc.relation.ispartof: | Current Drug Delivery |
| Appears in Collections: | Artigo de Periódico |
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