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http://hdl.handle.net/1843/63531| Type: | Artigo de Periódico |
| Title: | CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma |
| Authors: | Luan César da Silva Felipe Paiva Fonseca Oslei Paes de Almeida Bruno Augusto Linhares de Almeida Mariz Márcio Ajudarte Lopes Raghu Radhakrishnan Mohit Sharma Luiz Paulo Kowalski Pablo Agustin Vargas |
| Abstract: | Background: The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Material and methods: Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. Results: A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. Conclusion: The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation. |
| Subject: | Neoplasms Oral submucous fibrosis Carcinoma, squamous cell Immunity Dendritic cells Leukoplakia, oral Langerhans cells Antigens |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.4317%2Fmedoral.23177 |
| URI: | http://hdl.handle.net/1843/63531 |
| Issue Date: | 24-Dec-2019 |
| metadata.dc.url.externa: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982989/ |
| metadata.dc.relation.ispartof: | Medicina oral patología oral y cirugía bucal |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma.pdf | 459.22 kB | Adobe PDF | View/Open |
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