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http://hdl.handle.net/1843/64075| Type: | Artigo de Periódico |
| Title: | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| Authors: | Sandro Soares Almeida Flávia Campos Corgosinho Carlos EN Amorim Marcos Fernandes Gregnani Raquel Munhoz da Silveira Campos Deborah Cristina Landi Masquio Priscila de Lima Sanches Aline de Piano Ganen João Bosco Pesquero Ana Raimunda Dâmaso Marco Tulio de Mello Sergio Tufik Ronaldo Carvalho Araújo |
| Abstract: | Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents.Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes.Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response.Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy. |
| Subject: | Síndrome metabólica Obesidade Enzima conversora da angiotensina Polimorfismo genético |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE ESPORTES |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1177/1470320317703451 |
| URI: | http://hdl.handle.net/1843/64075 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://journals.sagepub.com/doi/10.1177/1470320317703451 |
| metadata.dc.relation.ispartof: | Journal of the Renin-Angiotensin-Aldosterone System |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I_D polymorphism.pdf | 2.39 MB | Adobe PDF | View/Open |
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