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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/65107
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dc.creatorErik de Oliveira Martinspt_BR
dc.creatorVivianne Basílio Barbosapt_BR
dc.creatorGerald Weberpt_BR
dc.date.accessioned2024-03-04T12:21:46Z-
dc.date.available2024-03-04T12:21:46Z-
dc.date.issued2019-
dc.citation.volume715pt_BR
dc.citation.spage14pt_BR
dc.citation.epage19pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.cplett.2018.11.015pt_BR
dc.identifier.issn0009-2614pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/65107-
dc.description.resumoDespite the importance of DNA/RNA hybrids, a mesoscopic approach is still missing. We developed a mesoscopic model for DNA/RNA hybrids and obtained the complete parametrization from published melting temperatures. The new parameters show very clearly the reduced strength of the hydrogen bond of dArU base pairs, resulting in a weakened stabilization of the double helix and a strong stability dependence on deoxypyrimidine content. The stacking parameters show no correlation to B-DNA, however we obtain a moderate correlation to A-RNA. We discuss some example sequences with variable deoxypyrimidine contents and for polipurine tracts (PPT).pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofChemical Physics Letters-
dc.rightsAcesso Restritopt_BR
dc.subjectDNA/RNA hybridpt_BR
dc.subjectPeyrard-Bishop DNA modelpt_BR
dc.subjectDNA/RNA stabilitypt_BR
dc.subjectHydrogen bondspt_BR
dc.subjectStacking interactionpt_BR
dc.subject.otherBiofísicapt_BR
dc.subject.otherÁcido desoxirribonucleicopt_BR
dc.subject.otherDNApt_BR
dc.subject.otherHidrogêniopt_BR
dc.titleDNA/RNA hybrid mesoscopic model shows strong stability dependence with deoxypyrimidine content and stacking interactions similar to RNA/RNApt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0009261418309291?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4480-6298pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2935-1571pt_BR
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