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http://hdl.handle.net/1843/65379| Tipo: | Artigo de Periódico |
| Título: | Clinicopathological analysis of oral and maxillofacial Acinic cell carcinoma: a systematic review |
| Autor(es): | Laura Borges Kirschnick Vivian Petersen Wagner Felipe Paiva Fonseca Manoela Domingues Martins Felipe Martins Silveira Lauren Frenzel Schuch Marco Antonio Martins Márcio Ajudarte Lopes Alan Roger dos Santos-Silva Vinicius Coelho Carrard Jean Nunes dos Santos Pablo Agustin Vargas |
| Resumen: | Background: The aim of the present systematic review was to analyze the available data regarding acinic cell carcinoma of the oral and maxillofacial region. Methods: A search strategy was performed using PubMed, Web of Science, Scopus, and Embase electronic databases. Results: Available data revealed a slight female preference (54.73%) and a mean age at diagnosis of 47.51 ± 19.85 years. The parotid glands (67.72%) were most frequently affected, and most cases were asymptomatic (69.54%). A microcystic histopathological pattern was reported in 21.56% of the cases, and the Periodic acid-Schiff was the staining method most frequently used, after the hematoxylin and eosin staining, in the tumors analyzed. The lesions were mainly treated by surgical removal (72.32%). Recurrence was reported in 81 cases (27.83%) and metastasis in 100 (42.91%). Statistical data analysis revealed that tumors located in major salivary glands and exhibiting high-grade histology were associated with local recurrence (P = .01). In addition, the patients older than 57 years, lesions with bone involvement, the high-grade tumors and the cases with a history of recurrence and metastasis were associated with a lower overall survival (P < .05). Conclusion: By assembling all eligible cases in the literature, the present systematic review determined the most common clinicopathological profile of acinic cell carcinoma and the most relevant prognostic factors in a distinctly representative sample. The survey demonstrated the importance of considering the histopathological grading in order to better define the treatment for each case. |
| Asunto: | Carcinoma, Acinar cell Mouth neoplasms Prognosis Parotid gland Recurrence Neoplasm metastasis |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1111/jop.13159 |
| URI: | http://hdl.handle.net/1843/65379 |
| Fecha del documento: | 2021 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.13159 |
| metadata.dc.relation.ispartof: | Journal of oral pathology & medicine |
| Aparece en las colecciones: | Artigo de Periódico |
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