Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/66225| Type: | Artigo de Periódico |
| Title: | Oral tolerance as antigen-specific immunotherapy |
| Authors: | Natália Pinheiro Rosa Lícia Torres Mariana de Almeida Oliveira Marcos Felipe Andrade-oliveira Mauro Andrade de Freitas Guimarães Monique Macedo Coelho Juliana de Lima Alves Tatiani Uceli Maioli Ana M. Caetano Faria |
| Abstract: | Oral tolerance is a physiological phenomenon described more than a century ago as a suppressive immune response to antigens that gain access to the body by the oral route. It is a robust and long-lasting event with local and systemic effects in which the generation of mucosally induced regulatory T cells (iTreg) plays an essential role. The idea of using oral tolerance to inhibit autoimmune and allergic diseases by oral administration of target antigens was an important development that was successfully tested in 1980s. Since then, several studies have shown that feeding specific antigens can be used to prevent and control chronic inflammatory diseases in both animal models and clinically. Therefore, oral tolerance can be classified as an antigen-specific form of oral immunotherapy (OIT). In the light of novel findings on mechanisms, sites of induction and factors affecting oral tolerance, this review will focus on specific characteristics of oral tolerance induction and how they impact in its therapeutic application. |
| Subject: | Imunologia Imunoterapia Mucosa bucal Linfócitos T Reguladores |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENF - DEPARTAMENTO DE NUTRIÇÃO ENFERMAGEM - ESCOLA DE ENFERMAGEM ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1093/immadv/ltab017 |
| URI: | http://hdl.handle.net/1843/66225 |
| Issue Date: | 25-Aug-2021 |
| metadata.dc.url.externa: | https://academic.oup.com/immunotherapyadv/article/1/1/ltab017/6357638 |
| metadata.dc.relation.ispartof: | Immunotherapy Advances |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Oral tolerance as antigen-specific immunotherapy.pdf | 368.65 kB | Adobe PDF | View/Open |
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