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http://hdl.handle.net/1843/67137| Type: | Artigo de Periódico |
| Title: | A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet |
| Authors: | Maria Luíza R. P. Lima Laura H. R. Leite Carolina R. Gioda Fabiola de Oliveira Paes Leme Claudia A. Couto Cândido C. Coimbra Virginia H. R. Leite Teresa Cristina A. Ferrari |
| Abstract: | The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the metabolic abnormalities associated with this disorder. Sixty Wistar rats were randomly separated into experimental and control groups, which were fed with sucrose-enriched (18% simple carbohydrates) and standard diet, respectively. At the end of each experimental period (5, 10, 20, and 30 weeks), 6 animals from each group were sacrificed for blood tests and liver histology and immunohistochemistry. From weeks 25 to 30, 6 animals from each group underwent physical training. The experimental group animals developed obesity and NAFLD, characterized histopathologically by steatosis and hepatocellular ballooning, clinically by increased thoracic circumference and body mass index associated with hyperleptinemia, and metabolically by hyperglycemia, hyperinsulinemia, hypertriglyceridemia, increased levels of very low-density lipoprotein- (VLDL-) cholesterol, depletion of the antioxidants liver enzymes superoxide dismutase and catalase, and increased hepatic levels of malondialdehyde, an oxidative stress marker. Rats that underwent physical training showed increased high-density lipoprotein- (HDL-) cholesterol levels. In conclusion, a sucrose-rich diet induced obesity, insulin resistance, oxidative stress, and NAFLD in rats. |
| Subject: | Ratos Wistar Hepatopatia gordurosa não alcoólica Sacarose na dieta Obesidade |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA MED - DEPARTAMENTO DE CLÍNICA MÉDICA VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1155/2016/9127076 |
| URI: | http://hdl.handle.net/1843/67137 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.hindawi.com/journals/jdr/2016/9127076/ |
| metadata.dc.relation.ispartof: | Journal of Diabetes Research |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| A novel wistar rat model of obesity-related nonalcoholic fatty liver disease induced by sucrose-rich diet.pdf | 735.95 kB | Adobe PDF | View/Open |
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