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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/67437
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dc.creatorGregório Guilherme Almeidapt_BR
dc.creatorFernanda Morcatti Courapt_BR
dc.creatorJonata de Melo Barbieript_BR
dc.creatorAna Carolina Junqueira Mourapt_BR
dc.creatorFabiola de Oliveira Paes Lemept_BR
dc.creatorAdriane Pimenta da Costa-Valpt_BR
dc.date.accessioned2024-04-18T20:40:46Z-
dc.date.available2024-04-18T20:40:46Z-
dc.date.issued2021-
dc.citation.volume2021pt_BR
dc.identifier.doihttps://doi.org/10.1155/2021/3192960pt_BR
dc.identifier.issn2314-6141pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/67437-
dc.description.resumoDogs are the main reservoir of Leishmania infantum in endemic regions. Canine leishmaniasis, caused by L. infantum, can progress to a chronic disease resulting in death. Vaccines have been developed with a certain degree of success. The pathogenesis of this disease is not completely understood, especially in previously vaccinated dogs. We herein described clinical data, parasite load, serum levels of cytokines, and the reservoir potential in vdogs vaccinated with the fucose-mannose ligand (FML)/QuilA saponin vaccine (Leishmune™) naturally infected (Vi) and compared to vaccinated not infected dogs (Vn). Thirty-four dogs from private owners were divided into two groups: vaccinated/infected and vaccinated/uninfected. Clinical evaluation, hematological and biochemical parameters, and serum levels of cytokines were measured by conventional methods. The parasite burden in the bone marrow was measured by quantitative real-time PCR, and the transmissibility of parasites to sand flies was assessed by xenodiagnosis. Clinical, biochemical, and hematological parameters of vaccinated infected dogs were mostly normal. Vi dogs developed mild disease with low clinical scores. Serum levels of IL-10 were higher in Vi dogs, and a strong correlation was observed in IL-4 levels and the A/G ratio in Vi dogs. These results suggest a role of TH2 response in Vi dogs, although more data is needed to better understand the disease in vaccinated dogs.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentVET - DEPARTAMENTO DE CLÍNICA E CIRURGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBioMed Research Internationalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectVaccinespt_BR
dc.subjectCytokinespt_BR
dc.subjectVaccinated dogspt_BR
dc.subject.otherLeishmania infantumpt_BR
dc.subject.otherVacinaspt_BR
dc.subject.otherCitocinaspt_BR
dc.subject.otherCãespt_BR
dc.titleFML/QuilA-vaccinated dogs naturally infected with Leishmania infantum: serum cytokines, clinicopathological profile, and parasitological parameterspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.hindawi.com/journals/bmri/2021/3192960/pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1108-1160pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2243-3125pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1044-3473pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7555-1956pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4013-0147pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8995-9805pt_BR
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