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http://hdl.handle.net/1843/67847| Type: | Artigo de Periódico |
| Title: | Effects of high-dose bisphenol a on the mouse oral mucosa: a possible link with oral cancers |
| Authors: | Tatiana Fernandes Araujo Almeida Sicília Rezende Oliveira Janine Mayra da Silva Ana Laura Fernandes de Oliveira Zenilda de Lourdes Cardeal Helvécio Costa Menezes José Messias Gomes Gabriel Henrique Campolina silva Cleida Aparecida Oliveira Soraia Macari Gustavo Pompermaier Garlet Ivana Márcia Alves Diniz Andréia Machado Leopoldino Tarcília Aparecida Silva |
| Abstract: | Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. We evaluated the oral mucosa of mice chronically exposed to BPA (200 mg/L). The response of keratinocytes (NOK–SI) and Head and Neck (HN) Squamous Cell Carcinoma (SCC), HN12 and HN13 cell lines to BPA was examined. In vivo, BPA accumulated in oral tissues and caused an increase in epithelial proliferative activity. BPA disrupted the function of keratinocytes by altering pro-survival and proliferative pathways and the secretion of cytokines and growth factors. In tumor cells, BPA induced proliferative, invasive, pro-angiogenic, and epigenetic paths. Our data highlight the harmful effects of BPA on oral mucosa and, tumorigenic and non-tumorigenic cells. Additionally, BPA may be a modifier of oral cancer cell behavior by prompting a functional shift to a more aggressive phenotype. |
| Subject: | Celulas - Cultura e meios de cultura. Tumores Estrogenos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - DEPARTAMENTO DE MORFOLOGIA ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.envpol.2021.117296 |
| URI: | http://hdl.handle.net/1843/67847 |
| Issue Date: | 2021 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0269749121008782 |
| metadata.dc.relation.ispartof: | Environmental Pollution |
| Appears in Collections: | Artigo de Periódico |
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