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Type:	Artigo de Periódico
Title:	Gastrointestinal symptoms predictors of health-related quality of life in patients with inflammatory bowel disease
Authors:	James Varni Robert Shulman Mariella Self Shehzad Saeed Ashish Patel Samuel Nurko Deborah Neigut Miguel Saps James Franciosi Jolanda Denham George Zacur Chelsea Dark Cristiane Baccin Bendo Neves John Pohl
Abstract:	Objectives: The aim of the study was to investigate the multidimensional gastrointestinal symptoms predictors of generic health-related quality of life (HRQOL) in pediatric patients with inflammatory bowel disease from the perspectives of pediatric patients and parents. Methods: The Pediatric Quality of Life Inventory Gastrointestinal Symptoms Scales and Pediatric Quality of Life Inventory 4.0 Generic Core Scales were completed in a 9-site study by 260 families of patients with inflammatory bowel disease. Gastrointestinal Symptoms Scales measuring stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were identified as clinically important symptom differentiators from healthy controls based on prior findings, and subsequently tested for bivariate and multivariate linear associations with overall HRQOL (Generic Core Scales). Results: Stomach pain, food and drink limits, gas and bloating, constipation, blood in stool, and diarrhea were significantly associated with decreased HRQOL in bivariate analyses (P < 0.001). In predictive models utilizing hierarchical multiple regression analyses controlling for age, sex, and race/ethnicity, gastrointestinal symptoms accounted for an additional 40% of the variance in patient self-reported HRQOL (P < 0.001) and 37% of the variance in parent proxy-reported HRQOL (P < 0.001), reflecting large effect sizes. Stomach pain, food and drink limits, and constipation were significant individual patient-reported predictors after controlling for the other gastrointestinal symptoms in the predictive models. Conclusions: Patient-reported gastrointestinal symptoms differentially predicted HRQOL. Identifying the specific gastrointestinal symptoms from a standardized multidimensional gastrointestinal symptoms profile that are the most important predictors from the patient perspective facilitates a patient-centered approach for interventions designed to ameliorate impaired HRQOL.
Subject:	Crohn disease Local symptoms Inflammatory bowel diseases Patient reported outcome measures Indicators of quality of life Colitis, ulcerative
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1097/MPG.0000000000001428
URI:	http://hdl.handle.net/1843/68150
Issue Date:	Dec-2016
metadata.dc.url.externa:	https://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001428
metadata.dc.relation.ispartof:	Journal of Pediatric Gastroenterology and Nutrition
Appears in Collections:	Artigo de Periódico

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