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http://hdl.handle.net/1843/68230| Tipo: | Artigo de Periódico |
| Título: | Release of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur |
| Autor(es): | Gabriel Antônio dos Anjos Tou José Messias Gomes Luíza Santana de Oliveira Rinco Monica Yamauti Ivana Márcia Alves Diniz Fabiane Pires Marcella Emilia Petra Schmidt Helvécio Costa Menezes Zenilda de Lourdes Cardeal Carla Beatriz Grespan Bottoli Soraia Macari |
| Resumen: | To evaluate the release of bisphenol-A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), bisphenol A (BPA), and phthalates of the composite resin used in the bonding of spurs applied in the treatment of children with anterior open bite and its effects on human keratinocytes. Methodology: Saliva samples of 22 children were collected before spur attachment (baseline) and 30 minutes (min) and 24 hours (h) after spur bonding. Analysis was performed using high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (HPLC–MS/ MS) and gas chromatography coupled to mass spectrometry (GC–MS). Standardized resin increments were added to three different dilutions of the cell culture medium. Keratinocytes (HaCaT) were cultivated in the conditioned media and evaluated for cell viability (MTT) and cell scratch assay. Results: The levels of BisGMA (1.74±0.27 μg/mL), TEGDMA (2.29±0.36 μg/mL), and BPA (3.264±0.88 μg/L) in the saliva after 30 min, in comparison to baseline (0±0 μg/mL, 0±0 μg/mL, and 1.15±0.21 μg/L, respectively), presented higher numbers. After 24 h, the levels of the monomers were similar to the baseline. Phthalates showed no significant difference among groups. HaCat cells showed increased viability and reduced cell migration over time after exposure to methacrylate-based resin composites. Conclusion: Resin composites, used to attach spurs in children with anterior open bite during orthodontic treatment, release monomers after polymerization and can influence the behavior of human keratinocytes, even at very low concentrations. Orthodontists should be aware of the risks of the resinous compounds release and preventive procedures should be held to reduce patient exposure. |
| Asunto: | Compostos orgânicos Resinas dentárias Cromatografia liquida de alta eficiencia Espectrometria de massa Cromatografia a gás |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1590/1678-7757-2022-0227 |
| URI: | http://hdl.handle.net/1843/68230 |
| Fecha del documento: | 2022 |
| metadata.dc.url.externa: | https://www.scielo.br/j/jaos/a/sT8WBdmtYJBNt46DpwgXhSK |
| metadata.dc.relation.ispartof: | Journal of Applied Oral Science |
| Aparece en las colecciones: | Artigo de Periódico |
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| archivo | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Release of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur (1).pdf | 813.6 kB | Adobe PDF | Visualizar/Abrir |
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