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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/68230
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dc.creatorGabriel Antônio dos Anjos Toupt_BR
dc.creatorJosé Messias Gomespt_BR
dc.creatorLuíza Santana de Oliveira Rincopt_BR
dc.creatorMonica Yamautipt_BR
dc.creatorIvana Márcia Alves Dinizpt_BR
dc.creatorFabiane Pirespt_BR
dc.creatorMarcella Emilia Petra Schmidtpt_BR
dc.creatorHelvécio Costa Menezespt_BR
dc.creatorZenilda de Lourdes Cardealpt_BR
dc.creatorCarla Beatriz Grespan Bottolipt_BR
dc.creatorSoraia Macaript_BR
dc.date.accessioned2024-05-13T14:54:21Z-
dc.date.available2024-05-13T14:54:21Z-
dc.date.issued2022-
dc.citation.volume30pt_BR
dc.identifier.doihttps://doi.org/10.1590/1678-7757-2022-0227pt_BR
dc.identifier.issn1678-7765pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/68230-
dc.description.resumoTo evaluate the release of bisphenol-A glycidyl methacrylate (BisGMA), triethylene glycol dimethacrylate (TEGDMA), bisphenol A (BPA), and phthalates of the composite resin used in the bonding of spurs applied in the treatment of children with anterior open bite and its effects on human keratinocytes. Methodology: Saliva samples of 22 children were collected before spur attachment (baseline) and 30 minutes (min) and 24 hours (h) after spur bonding. Analysis was performed using high-performance liquid chromatography (HPLC) coupled to tandem mass spectrometry (HPLC–MS/ MS) and gas chromatography coupled to mass spectrometry (GC–MS). Standardized resin increments were added to three different dilutions of the cell culture medium. Keratinocytes (HaCaT) were cultivated in the conditioned media and evaluated for cell viability (MTT) and cell scratch assay. Results: The levels of BisGMA (1.74±0.27 μg/mL), TEGDMA (2.29±0.36 μg/mL), and BPA (3.264±0.88 μg/L) in the saliva after 30 min, in comparison to baseline (0±0 μg/mL, 0±0 μg/mL, and 1.15±0.21 μg/L, respectively), presented higher numbers. After 24 h, the levels of the monomers were similar to the baseline. Phthalates showed no significant difference among groups. HaCat cells showed increased viability and reduced cell migration over time after exposure to methacrylate-based resin composites. Conclusion: Resin composites, used to attach spurs in children with anterior open bite during orthodontic treatment, release monomers after polymerization and can influence the behavior of human keratinocytes, even at very low concentrations. Orthodontists should be aware of the risks of the resinous compounds release and preventive procedures should be held to reduce patient exposure.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Applied Oral Sciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMethacrylatespt_BR
dc.subjectBisphenol-A glycidyl methacrylatept_BR
dc.subjectDibutyl phthalatept_BR
dc.subjectKeratinocytespt_BR
dc.subjectOpen bitept_BR
dc.subject.otherCompostos orgânicospt_BR
dc.subject.otherResinas dentáriaspt_BR
dc.subject.otherCromatografia liquida de alta eficienciapt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.subject.otherCromatografia a gáspt_BR
dc.titleRelease of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spurpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/jaos/a/sT8WBdmtYJBNt46DpwgXhSKpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-4697-5503pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-3246-3301pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-0675-9053pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-0886-4407pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-4261-0037pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-9947-0261pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-2050-0729pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-5759-612Xpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-1383-6299pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-5605-6976pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-7643-6589pt_BR
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