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http://hdl.handle.net/1843/68726| Tipo: | Artigo de Periódico |
| Título: | International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil |
| Autor(es): | Marcelo Pires Nogueira de Carvalho Miriam R. Fernandes Fábio P. Sellera Ralf Lopes Daniel F. Monte Alícia G. Hippólito Liliane Milanelo Tânia F. Raso Nilton Lincopan |
| Resumen: | CTX-M-type extended-spectrum β-lactamase (ESBL)-producing Escherichia coli clones have been increasingly reported worldwide. In this regard, although discussions of transmission routes of these bacteria are in evidence, molecular data are lacking to elucidate the epidemiological impacts of ESBL producers in wild animals. In this study, we have screened 90 wild animals living in a surrounding area of São Paulo, the largest metropolitan city in South America, to monitor the presence of multidrug-resistant (MDR) Gram-negative bacteria. Using a genomic approach, we have analysed eight ceftriaxone-resistant E. coli. Resistome analyses revealed that all E. coli strains carried blaCTX-M-type genes, prevalent in human infections, besides other clinically relevant resistance genes to aminoglycosides, β-lactams, phenicols, tetracyclines, sulphonamides, trimethoprim, fosfomycin and quinolones. Additionally, E. coli strains belonged to international sequence types (STs) ST38, ST58, ST212, ST744, ST1158 and ST1251, and carried several virulence-associated genes. Our findings suggest spread and adaptation of international clones of CTX-M-producing E. coli beyond urban settings, including wildlife from shared environments. |
| Asunto: | Escherichia coli Bactérias Gram-Negativas Animais selvagens |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | VET - DEPARTAMENTO DE CLÍNICA E CIRURGIA |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1111/tbed.13558 |
| URI: | http://hdl.handle.net/1843/68726 |
| Fecha del documento: | 2020 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/tbed.13558 |
| metadata.dc.relation.ispartof: | Transboundary and Emerging Diseases |
| Aparece en las colecciones: | Artigo de Periódico |
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| archivo | Descripción | Tamaño | Formato | |
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| International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.pdf | 1.39 MB | Adobe PDF | Visualizar/Abrir |
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