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http://hdl.handle.net/1843/69135| Tipo: | Artigo de Periódico |
| Título: | Aggregatibacter actinomycetemcomitans serotypes and JP2 outcomes related to clinical status over 6 years under periodontal maintenance therapy |
| Autor(es): | José Roberto Cortelli Sheila Cavalca Cortelli Davi Romeiro Aquino Taís Browne Miranda João Carlos Moreira Jardim Fernando de Oliveira Costa |
| Resumo: | Objective: This 6-year study evaluatedAggregatibacter actinomycetemcomitans outcomes and their relationship to clinical status. Design: From the eligible individuals (23-70 years of age), 31 regular compliers (between-visit interval < 6 months) were randomly selected and matched for age/sex with 31 irregular compliers (between-visit interval > 6 months). Periodontal clinical examination and subgingival samples were obtained 5 times: T1 (baseline), T2 (after active periodontal therapy), T3 (2 years), T4 (4 years), and T5 (6 years). Total bacteria load, A. actinomycetemcomitans, and red complex species Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola levels were determined by qPCR while PCR was used to determine the occurrence of the a-b-c-d-e-f-g serotypes and the JP2 clone of A. actinomycetemcomitans. Data between groups was compared over time. Results: At baseline PCR revealed A. actinomycetemcomitans prevalence of 9.7 % and JP2 prevalence of 6.7 %. A. actinomycetemcomitans qPCR levels were higher among individuals < 35 years of age and increased at T2 in irregular compliers. At in irregular compliers at the three follow-up visits. Serotypes a, d, and f showed greater values in at least one follow-up visit in regular compliers. A. actinomycetemcomitans showed negative correlation with probing depth (PD) while serotype b showed negative correlations with PD, PI, clinical attachment level and red complex. Conclusions: Longitudinally, compliance during PMT contributed to lower A. actinomycetemcomitans levels with some degree of correlation with clinical status. However, this study failed to report any positive effect on the occurrence of the most virulent representatives, i.e. serotype b and the JP2 clone. |
| Assunto: | Aggregatibacter actinomycetemcomitans Compliance Exotoxins Porphyromonas gingivalis Longitudinal studies Tannerella forsythia Treponema denticola Serogroup Therapeutics |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1016/j.archoralbio.2020.104747 |
| URI: | http://hdl.handle.net/1843/69135 |
| Data do documento: | Ago-2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0003996920301254?via%3Dihub |
| metadata.dc.relation.ispartof: | Archives of Oral Biology |
| Aparece nas coleções: | Artigo de Periódico |
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