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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69178
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dc.creatorMônica Versiani Nunes Pinheiro de Queirozpt_BR
dc.creatorJoana Versiani Chiabi de Queirozpt_BR
dc.creatorLaura Maria de Lima Belizário Facury Lasmarpt_BR
dc.date.accessioned2024-06-12T20:56:19Z-
dc.date.available2024-06-12T20:56:19Z-
dc.date.issued2017-
dc.citation.volume5pt_BR
dc.citation.issue1pt_BR
dc.identifier.issn2333-6625pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69178-
dc.description.resumoThe objective of this study was to review the last 16 years of literature on the clinical and functional risk factors for asthma exacerbation, as well as on biochemical parameters in severe pediatric asthma refractory to treatment (SPART). In searches of the Cochrane/Brazilian Virtual Library of Health, Latin American and Caribbean Health Sciences Literature, Medline, Brazilian Office for the Advancement of Higher Education, and PubMed databases, we employed the following search terms/strings: “severe asthma” or “refractory asthma” or “problematic asthma” or “difficult-to-treat asthma”; “exacerbation”; “risk factors” or “predictors”; and “pediatric” or “children and adolescents”. We limited our searches to articles published between 1999 and 2016. We selected 26 original or review articles on severe pediatric asthma that addressed age, recent severe exacerbations, the level of asthma control, regular follow-up, comorbidities, behavioral factors, viral infection, and passive smoking, biomarkers of inflammation, serum vitamin D levels, and pulmonary function. However, we found very few studies dealing with SPART. Severe asthma is a heterogeneous, dynamic disease in which the various predictors of exacerbation described assess different aspects of the disease and are complementary. Such factors should be analyzed from a multifactorial and individualized perspective, because many of them are potentially modifiable.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Research in Pulmonologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSevere refractory asthmapt_BR
dc.subjectChildren and adolescentspt_BR
dc.subjectPredictive factorspt_BR
dc.subjectExacerbationpt_BR
dc.subject.otherAsmapt_BR
dc.subject.otherCriançapt_BR
dc.subject.otherAdolescentept_BR
dc.subject.otherValor preditivo dos testespt_BR
dc.subject.otherProgressão da doençapt_BR
dc.titleSevere pediatric asthma refractory to treatment: the ongoing challenge of exacerbationpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.jscimedcentral.com/jounal-article-info/Clinical-Research-in-Pulmonology/Severe-Pediatric-Asthma--Refractory-to-Treatment%3A--The-Ongoing-Challenge-of--Exacerbation-2398#pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3183-0990pt_BR
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