Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/69178| Type: | Artigo de Periódico |
| Title: | Severe pediatric asthma refractory to treatment: the ongoing challenge of exacerbation |
| Authors: | Mônica Versiani Nunes Pinheiro de Queiroz Joana Versiani Chiabi de Queiroz Laura Maria de Lima Belizário Facury Lasmar |
| Abstract: | The objective of this study was to review the last 16 years of literature on the clinical and functional risk factors for asthma exacerbation, as well as on biochemical parameters in severe pediatric asthma refractory to treatment (SPART). In searches of the Cochrane/Brazilian Virtual Library of Health, Latin American and Caribbean Health Sciences Literature, Medline, Brazilian Office for the Advancement of Higher Education, and PubMed databases, we employed the following search terms/strings: “severe asthma” or “refractory asthma” or “problematic asthma” or “difficult-to-treat asthma”; “exacerbation”; “risk factors” or “predictors”; and “pediatric” or “children and adolescents”. We limited our searches to articles published between 1999 and 2016. We selected 26 original or review articles on severe pediatric asthma that addressed age, recent severe exacerbations, the level of asthma control, regular follow-up, comorbidities, behavioral factors, viral infection, and passive smoking, biomarkers of inflammation, serum vitamin D levels, and pulmonary function. However, we found very few studies dealing with SPART. Severe asthma is a heterogeneous, dynamic disease in which the various predictors of exacerbation described assess different aspects of the disease and are complementary. Such factors should be analyzed from a multifactorial and individualized perspective, because many of them are potentially modifiable. |
| Subject: | Asma Criança Adolescente Valor preditivo dos testes Progressão da doença |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE PEDIATRIA |
| Rights: | Acesso Aberto |
| URI: | http://hdl.handle.net/1843/69178 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.jscimedcentral.com/jounal-article-info/Clinical-Research-in-Pulmonology/Severe-Pediatric-Asthma--Refractory-to-Treatment%3A--The-Ongoing-Challenge-of--Exacerbation-2398# |
| metadata.dc.relation.ispartof: | Clinical Research in Pulmonology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Severe pediatric asthma refractory to treatment_ the ongoing challenge of exacerbation.pdf | 436.58 kB | Adobe PDF | View/Open |
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