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Tipo:	Artigo de Periódico
Título:	Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Autor(es):	Isabela M. Bensenor Alessandra C. Goulart Alexandre C. Pereira André R. Brunoni Airlane Alencar Raul D. Santos Márcio S. Bittencourt Rosa Weiss Telles Luciana Andrade Carneiro Machado Sandhi Maria Barreto Bianca de Almeida-Pititto Carolina Porto Silva Janovsky José Augusto Sgarb William R. Tebar Vandrize Meneghini Fernando Barbosa Junior Ana Cristina de Medeiros Ribeiro Sandra Gofinet Pasoto Rosa Maria R. Pereira Eloísa Bonfá Aytan M. Sipahi Itamar de S. Santos Paulo A. Lotufo
Resumen:	Objectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.
Asunto:	Doença crônica Doenças cardiovasculares Espessura intima-media carotídea Aterosclerose
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Institución:	UFMG
Departamento:	MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
Tipo de acceso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1016/j.clinsp.2022.100013
URI:	http://hdl.handle.net/1843/69260
Fecha del documento:	2022
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S1807593222000096?via%3Dihub
metadata.dc.relation.ispartof:	Clinics
Aparece en las colecciones:	Artigo de Periódico

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