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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69260
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dc.creatorIsabela M. Bensenorpt_BR
dc.creatorAlessandra C. Goulartpt_BR
dc.creatorAlexandre C. Pereirapt_BR
dc.creatorAndré R. Brunonipt_BR
dc.creatorAirlane Alencarpt_BR
dc.creatorRaul D. Santospt_BR
dc.creatorMárcio S. Bittencourtpt_BR
dc.creatorRosa Weiss Tellespt_BR
dc.creatorLuciana Andrade Carneiro Machadopt_BR
dc.creatorSandhi Maria Barretopt_BR
dc.creatorBianca de Almeida-Pitittopt_BR
dc.creatorCarolina Porto Silva Janovskypt_BR
dc.creatorJosé Augusto Sgarbpt_BR
dc.creatorWilliam R. Tebarpt_BR
dc.creatorVandrize Meneghinipt_BR
dc.creatorFernando Barbosa Juniorpt_BR
dc.creatorAna Cristina de Medeiros Ribeiropt_BR
dc.creatorSandra Gofinet Pasotopt_BR
dc.creatorRosa Maria R. Pereirapt_BR
dc.creatorEloísa Bonfápt_BR
dc.creatorAytan M. Sipahipt_BR
dc.creatorItamar de S. Santospt_BR
dc.creatorPaulo A. Lotufopt_BR
dc.date.accessioned2024-06-18T15:54:59Z-
dc.date.available2024-06-18T15:54:59Z-
dc.date.issued2022-
dc.citation.volume77pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.clinsp.2022.100013pt_BR
dc.identifier.issn1807-5932pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69260-
dc.description.resumoObjectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinicspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectChronic Inflammatory diseasept_BR
dc.subjectCardiovascular diseasept_BR
dc.subjectCoronary artery calcium (CAC)pt_BR
dc.subjectCarotid intima-media thickness (CIMT)pt_BR
dc.subjectFatal and non-fatal cardiovascular eventspt_BR
dc.subject.otherDoença crônicapt_BR
dc.subject.otherDoenças cardiovascularespt_BR
dc.subject.otherEspessura intima-media carotídeapt_BR
dc.subject.otherAterosclerosept_BR
dc.titleChronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1807593222000096?via%3Dihubpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0003-4027-2943pt_BR
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