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http://hdl.handle.net/1843/69366| Type: | Artigo de Periódico |
| Title: | Impact of non-surgical periodontal treatment on serum TNF-α levels in individuals with type 2 Diabetes: a systematic review and meta-analysis |
| Authors: | Rafael Paschoal Esteves Lima Andressa Rafaela Silva Atanazio Fernando de Oliveira Costa Fabiano Araújo Cunha Lucas Guimarães Abreu |
| Abstract: | Objective The objective of this systematic review and meta-analysis was to search for scientific evidence on the impact of non-surgical periodontal therapy on tumor necrosis factor alpha (TNF-α) in type 2 diabetics. Methods The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement has been followed. The study was registered (CRD42020192790) in the International prospective register of systematic reviews. Searches were conducted in five databases. Restrictions on publication date were not imposed in anyway. The studies reporting the serum TNF-α levels of individuals with type 2 diabetes mellitus (DM) before and after non-surgical periodontal therapy were included. Studies’ selection, extraction of data and risk of bias assessment were performed in duplicate. Consensus was achieved. Meta‐analysis was carried out. The 95% confidence interval and odds ratio were provided. Results Six hundred and twenty-three references were retrieved and eighteen studies were included. Meta-analysis demonstrated that the serum levels of TNF-α in individuals with type 2 DM decreased six months after non-surgical periodontal therapy (mean difference = -1.90, confidence interval = -3.05–-0.74). Included studies presented low risk of bias. Conclusion Non-surgical periodontal therapy has an impact on serum TNF-α levels at six months in type 2 DM patients. |
| Subject: | Diabetes Mellitus, Type 2 Periodontitis Tumor necrosis factor-alpha Therapeutics Network meta-analysis Systematic review |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOPEDIATRIA E ORTODONTIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jebdp.2021.101546 |
| URI: | http://hdl.handle.net/1843/69366 |
| Issue Date: | Jun-2021 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S153233822100021X |
| metadata.dc.relation.ispartof: | Journal of Evidence Based Dental Practice |
| Appears in Collections: | Artigo de Periódico |
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