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http://hdl.handle.net/1843/69622| Tipo: | Artigo de Periódico |
| Título: | Simultaneous occurrence of epstein-barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study |
| Autor(es): | Humberto Jácome-Santos Ricardo Alves de Mesquita Sérgio de Melo Alves-Junior Naira da Silva e Silva Renata Gonçalves Resende Helder Henrique Costa Pinheiro Luiz Fernando Almeida Machado Guilherme de Souza Silva Igor Brasil-Costa Fernando de Oliveira Costa Ana Cláudia Braga Amoras-Alves |
| Resumo: | Objectives: This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC. Methods: A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites. Results: The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05). Conclusions: We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated. Clinical relevance: The identification of this easily accessible site of EBV latent infection may help to improve the patient's quality of life by maintenance of oral/periodontal health condition and preventing further possible disorders related to the virus, and also encourages new approaches for investigating EBV, periodontitis, and OSCC. |
| Assunto: | Squamous cell carcinoma of head and neck Herpesvirus 4, human Periodontal pocket Neoplasms Periodontitis DNA, viral |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1007/s00784-021-04258-z |
| URI: | http://hdl.handle.net/1843/69622 |
| Data do documento: | 16-Nov-2021 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s00784-021-04258-z |
| metadata.dc.relation.ispartof: | Clinical Oral Investigations |
| Aparece nas coleções: | Artigo de Periódico |
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