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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/69622
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dc.creatorHumberto Jácome-Santospt_BR
dc.creatorRicardo Alves de Mesquitapt_BR
dc.creatorSérgio de Melo Alves-Juniorpt_BR
dc.creatorNaira da Silva e Silvapt_BR
dc.creatorRenata Gonçalves Resendept_BR
dc.creatorHelder Henrique Costa Pinheiropt_BR
dc.creatorLuiz Fernando Almeida Machadopt_BR
dc.creatorGuilherme de Souza Silvapt_BR
dc.creatorIgor Brasil-Costapt_BR
dc.creatorFernando de Oliveira Costapt_BR
dc.creatorAna Cláudia Braga Amoras-Alvespt_BR
dc.date.accessioned2024-07-03T17:47:52Z-
dc.date.available2024-07-03T17:47:52Z-
dc.date.issued2021-11-16-
dc.citation.volume26pt_BR
dc.citation.spage2807pt_BR
dc.citation.epage2815pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00784-021-04258-zpt_BR
dc.identifier.issn1436-3771pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/69622-
dc.description.resumoObjectives: This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC. Methods: A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites. Results: The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05). Conclusions: We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated. Clinical relevance: The identification of this easily accessible site of EBV latent infection may help to improve the patient's quality of life by maintenance of oral/periodontal health condition and preventing further possible disorders related to the virus, and also encourages new approaches for investigating EBV, periodontitis, and OSCC.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofClinical Oral Investigationspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectoral squamous cell carcinoma acesso restrito Simultaneous occurrence of epstein-barr virus (ebv) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study busca dia 02/07/2024pt_BR
dc.subjectEpstein-Barr vírus Keywords: Epstein-Barr virus; Oral squamous cell carcinoma; Periodontal pocket, Cancer; Periodontitis.pt_BR
dc.subjectPeriodontal pocketspt_BR
dc.subjectcross-sectional study Clinical oral investigations periódicopt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherHerpesvirus 4, humanpt_BR
dc.subject.otherPeriodontal pocketpt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherPeriodontitispt_BR
dc.subject.otherDNA, viralpt_BR
dc.titleSimultaneous occurrence of epstein-barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional studypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00784-021-04258-zpt_BR
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