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http://hdl.handle.net/1843/69771| Type: | Artigo de Periódico |
| Title: | Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status |
| Authors: | Paula Luize Camargos Fonseca Helena P. Coelho Alana V. B. Costa Walyson C. Costa Alex F. de Carvalho Bruna W. F. de Faria Aline Brito de Lima Eneida Santos de Oliveira Carolina Senra Alves de Souza Fernanda Gil de Souza Rillery C. Dias Filipe R. R. Moreira Victor E. V. Geddes Igor P. Godinho Alessandro L. Gonçalves Karine Lima Lourenço Rubens D. M. Magalhães Frederico Scott Varella Malta Eva L. A. Medeiros Fernanda Santos Mendes Pedro H. B. de P. Mendes Cristiane P. T. B. Mendonça Rafael M. de Souza Andre L. Menezes Diego Menezes Mariane Talon de Menezes Lucyene Miguita Luiz Rennan G. Moreira Renata B. Peixoto Daniel Costa Queiroz Adriana A. Ribeiro Ana Paula de B. Ribeiro Juliana Wilke Saliba Natalia Rocha Guimarães Hugo I. Sato Joice do P. Silva Natiely Pereira Silva Nuno R. Faria Santuza Maria Ribeiro Teixeira Flávio Guimarães da Fonseca Ana Paula Salles Moura Fernandes Danielle Alves Gomes Zauli José Nélio Januario Jaqueline Silva de Oliveira Nara de Oliveira Carvalho Felipe Campos de Melo Iani Renato Santana de Aguiar Renan Pedra de Souza Talita Émile Ribeiro Adelino Hugo José Alves Luige Biciati Alvim Darlan S. Candido |
| Abstract: | The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting. |
| Subject: | Filogenia Filogeografia Vacinas contra COVID-19 Vacinação SARS-CoV-2 |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1093/ve/veac064 |
| URI: | http://hdl.handle.net/1843/69771 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://academic.oup.com/ve/article/8/2/veac064/6650740?login=true |
| metadata.dc.relation.ispartof: | Virus Evolution |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status.pdf | 3.19 MB | Adobe PDF | View/Open |
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