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http://hdl.handle.net/1843/70470| Type: | Artigo de Periódico |
| Title: | Comparison of the effects of monastrol and oxomonastrol on human hepatoma cell line HepG2/C3A |
| Authors: | Lilian Areal Marques Simone Cristine Semprebon Daniele Sartori Ângelo de Fátima Lúcia Regina Ribeiro Mário Sérgio Mantovani |
| Abstract: | Monastrol and its analog oxomonastrol differ by replacement of the sulfur atom present in monastrol to an oxygen atom in oxomonastrol. Monastrol inhibits the mitotic kinesin family member 11 (EG5), which has been studied for its potential use in cancer therapy. The aim of this study was to investigate the effect of monastrol and oxomonastrol on HepG2/C3A cells. Our results showed that monastrol induced DNA damage, reduced cell proliferation, and up-regulated the cytochrome P450 family 1 subfamily A member 1 (CYP1A1) mRNA levels. However, oxomonastrol was cytotoxic only at the highest concentrations used, without reducing cell proliferation and viability. Moreover, no genotoxic damage or alteration of levels of mRNA were found. Our results suggest that monastrol has greater antiproliferative activity compared to oxomonastrol, and this effect is probably related to the DNA damage induced by monastrol and its possible bioactivation demonstrated by the increase in CYP1A1 mRNA expression. Moreover, these effects appear to be related to the presence of the sulfur atom in its structure. |
| Subject: | Morfologia Química Agentes antineoplásicos Apoptose Testes biológicos Microscopia de fluorescência Câncer - Quimioterapia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.21873/anticanres.11434 |
| URI: | http://hdl.handle.net/1843/70470 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://ar.iiarjournals.org/content/37/3/1197/tab-article-info |
| metadata.dc.relation.ispartof: | Anticancer Research |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Comparison of the Effects of Monastrol and Oxomonastrol.pdf | 274.51 kB | Adobe PDF | View/Open |
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