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http://hdl.handle.net/1843/70506
Type: | Artigo de Periódico |
Title: | Cocaethylene, the in vivo product of cocaine and ethanol, is a narcotic more potent than its precursors |
Authors: | Angélica Faleiros da Silva Maia Felipe Terra Martins Leonardo da Silva Neto Rosemeire Brondi Alves Ângelo de Fátima |
Abstract: | The molecular conformation and supramolecular architecture of cocaethylene [systematic name: ethyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate], C18H23NO4, have been determined for the first time. Cocaethylene is a narcotic produced in vivo when cocaine and ethanol are administered concomitantly. The intra- and intermolecular features of cocaethylene and its less potent narcotic precursor cocaine are very similar. The only molecular difference is in the conformation of the methyl group of the ethoxycarbonyl group. Similar to cocaine, the carboxylate atoms and the α-C atom are coplanar in cocaethylene, but the methyl C atom of the ethyl group is bent by ca 90° away from this plane in the narcotic reported here. The main supramolecular motif is a one-dimensional chain stabilized by weak C—H...O contacts. |
Subject: | Cocaina Narcóticos Cristalografia Química supramolecular |
language: | eng |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
Rights: | Acesso Restrito |
metadata.dc.identifier.doi: | https://doi.org/10.1107/S2053229617012852 |
URI: | http://hdl.handle.net/1843/70506 |
Issue Date: | 2017 |
metadata.dc.url.externa: | https://journals.iucr.org/paper?S2053229617012852 |
metadata.dc.relation.ispartof: | Acta Crystallographica Section C: Structural Chemistry |
Appears in Collections: | Artigo de Periódico |
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