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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/71096
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dc.creatorVidyleison N. camargospt_BR
dc.creatorVictória F. Queirozpt_BR
dc.creatorAna Carolina F. Diaspt_BR
dc.creatorKarina T. O. Santanapt_BR
dc.creatorIngredy Passospt_BR
dc.creatorAna Luíza C. V. Realpt_BR
dc.creatorLudmila C. Silvapt_BR
dc.creatorFlávio A. G. Mourãopt_BR
dc.creatorNatália T. Wnukpt_BR
dc.creatorMilton A. P. Oliveirapt_BR
dc.creatorSoraia Macaript_BR
dc.creatorGiselle Foureauxpt_BR
dc.creatorTarcília Silvapt_BR
dc.creatorGustavo P. Garletpt_BR
dc.creatorJoshua A. Jackmanpt_BR
dc.creatorFrederico M. Sorianipt_BR
dc.creatorMárcio F. D. Moraespt_BR
dc.creatorEduardo M. A. M. Mendespt_BR
dc.creatorFabíola M. Ribeiropt_BR
dc.creatorGuilherme M. J. Costapt_BR
dc.creatorAntônio L. Teixeirapt_BR
dc.creatorNam-Joon Chopt_BR
dc.creatorDaniel C. Medeirospt_BR
dc.creatorAntônio C. P. Oliveirapt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorVivian V. Costapt_BR
dc.creatorDanielle G. Souzapt_BR
dc.creatorVivian T. da Silveirapt_BR
dc.creatorCelso M. Queiroz-Juniorpt_BR
dc.creatorAna Luisa B. Matosinhospt_BR
dc.creatorAndré F. A. Figueiredopt_BR
dc.creatorCarla D. F. Sousapt_BR
dc.creatorThaiane P. Moreirapt_BR
dc.date.accessioned2024-07-19T21:40:34Z-
dc.date.available2024-07-19T21:40:34Z-
dc.date.issued2019-
dc.citation.volume44pt_BR
dc.citation.spage516pt_BR
dc.citation.epage529pt_BR
dc.identifier.doi10.1016/j.ebiom.2019.05.014pt_BR
dc.identifier.issn2352-3964pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/71096-
dc.description.resumoBackground: Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZIKV infection (CZI) in immunocompetent mice. Methods: Pregnant dams were inoculated with ZIKV on embryonic day 5.5 in the presence or absence of a sub-neutralizing dose of a pan-flavivirus monoclonal antibody (4G2) to evaluate the potential role of antibody-dependent enhancement phenomenon (ADE) during short and long outcomes of CZI. Findings: ZIKV infection induced maternal immune activation (MIA), which was associated with occurrence of foetal abnormalities and death. Therapeutic administration of AH-D antiviral peptide during the early stages of pregnancy prevented ZIKV replication and death of offspring. In the post-natal period, CZI was associated with a decrease in whole brain volume, ophthalmologic abnormalities, changes in testicular morphology, and disruption in bone microarchitecture. Some alterations were enhanced in the presence of 4G2 antibody. Interpretation: Our results reveal that early maternal ZIKV infection causes several birth defects in immunocompetent mice, which can be potentiated by ADE phenomenon and are associated with MIA. Additionally, antiviral treatment with AH-D peptide may be beneficial during early maternal ZIKV infection.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFINEP - Financiadora de Estudos e Projetos, Financiadora de Estudos e Projetospt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEBioMedicinept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherInfecção por Zika viruspt_BR
dc.subject.otherAnticorpos Facilitadorespt_BR
dc.subject.otherGestantespt_BR
dc.subject.otherImunidadept_BR
dc.titleIn-depth characterization of congenital Zika syndrome in immunocompetent mice: antibody-dependent enhancement and an antiviral peptide therapypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2352396419303159?via%3Dihubpt_BR
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