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http://hdl.handle.net/1843/71096| Type: | Artigo de Periódico |
| Title: | In-depth characterization of congenital Zika syndrome in immunocompetent mice: antibody-dependent enhancement and an antiviral peptide therapy |
| Authors: | Vidyleison N. camargos Victória F. Queiroz Ana Carolina F. Dias Karina T. O. Santana Ingredy Passos Ana Luíza C. V. Real Ludmila C. Silva Flávio A. G. Mourão Natália T. Wnuk Milton A. P. Oliveira Soraia Macari Giselle Foureaux Tarcília Silva Gustavo P. Garlet Joshua A. Jackman Frederico M. Soriani Márcio F. D. Moraes Eduardo M. A. M. Mendes Fabíola M. Ribeiro Guilherme M. J. Costa Antônio L. Teixeira Nam-Joon Cho Daniel C. Medeiros Antônio C. P. Oliveira Mauro Martins Teixeira Vivian V. Costa Danielle G. Souza Vivian T. da Silveira Celso M. Queiroz-Junior Ana Luisa B. Matosinhos André F. A. Figueiredo Carla D. F. Sousa Thaiane P. Moreira |
| Abstract: | Background: Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZIKV infection (CZI) in immunocompetent mice. Methods: Pregnant dams were inoculated with ZIKV on embryonic day 5.5 in the presence or absence of a sub-neutralizing dose of a pan-flavivirus monoclonal antibody (4G2) to evaluate the potential role of antibody-dependent enhancement phenomenon (ADE) during short and long outcomes of CZI. Findings: ZIKV infection induced maternal immune activation (MIA), which was associated with occurrence of foetal abnormalities and death. Therapeutic administration of AH-D antiviral peptide during the early stages of pregnancy prevented ZIKV replication and death of offspring. In the post-natal period, CZI was associated with a decrease in whole brain volume, ophthalmologic abnormalities, changes in testicular morphology, and disruption in bone microarchitecture. Some alterations were enhanced in the presence of 4G2 antibody. Interpretation: Our results reveal that early maternal ZIKV infection causes several birth defects in immunocompetent mice, which can be potentiated by ADE phenomenon and are associated with MIA. Additionally, antiviral treatment with AH-D peptide may be beneficial during early maternal ZIKV infection. |
| Subject: | Infecção por Zika virus Anticorpos Facilitadores Gestantes Imunidade |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ENG - DEPARTAMENTO DE ENGENHARIA ELETRÔNICA FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1016/j.ebiom.2019.05.014 |
| URI: | http://hdl.handle.net/1843/71096 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S2352396419303159?via%3Dihub |
| metadata.dc.relation.ispartof: | EBioMedicine |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| In-depth characterization of congenital Zika syndrome in immunocompetent mice- Antibody-dependent enhancement and an antiviral peptide therapy.pdf | 1.03 MB | Adobe PDF | View/Open |
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