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http://hdl.handle.net/1843/72110| Tipo: | Artigo de Periódico |
| Título: | On the synthesis of quinone-based BODIPY hybrids: new insights on antitumor activity and mechanism of action in cancer cells |
| Autor(es): | Talita Bárbara Gontijo Rossimiriam Pereira de Freitas Flavio da Silva Emery Leandro Ferreira Pedrosa José de Brito Vieira Neto Bruno Coêlho Cavalcanti Claudia do Ó Pessoa Aaron King Fabio de Moliner Marc Vendrell Eufrânio Nunes da Silva Júnior |
| Resumen: | Fluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR analysis and mass spectrometry. We measured their cytotoxic activity against cancer and normal cell lines, performed mechanistic studies by lipid peroxidation and determination of reduced (GSH) and oxidized (GSSG) glutathione, and imaged their subcellular localisation by confocal microscopy. Cell imaging experiments indicated that nor-β-lapachone-based BODIPY derivatives might preferentially localise in the lysosomes of cancer cells. These results assert the potential of hybrid quinone-BODIPY derivatives as promising prototypes in the search of new potent lapachone antitumor drugs. |
| Asunto: | Quinona Síntese Células cancerosas Ressonância magnética nuclear Espectrometria de massa Peroxidação Glutationa Microscopia Agentes antineoplásicos |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | ICX - DEPARTAMENTO DE QUÍMICA |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1016/j.bmcl.2017.08.007 |
| URI: | http://hdl.handle.net/1843/72110 |
| Fecha del documento: | 2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0960894X17307941 |
| metadata.dc.relation.ispartof: | Bioorganic & Medicinal Chemistry Letters |
| Aparece en las colecciones: | Artigo de Periódico |
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