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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72110
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dc.creatorTalita Bárbara Gontijopt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorFlavio da Silva Emerypt_BR
dc.creatorLeandro Ferreira Pedrosapt_BR
dc.creatorJosé de Brito Vieira Netopt_BR
dc.creatorBruno Coêlho Cavalcantipt_BR
dc.creatorClaudia do Ó Pessoapt_BR
dc.creatorAaron Kingpt_BR
dc.creatorFabio de Molinerpt_BR
dc.creatorMarc Vendrellpt_BR
dc.creatorEufrânio Nunes da Silva Júniorpt_BR
dc.date.accessioned2024-07-30T15:14:59Z-
dc.date.available2024-07-30T15:14:59Z-
dc.date.issued2017-
dc.citation.volume27pt_BR
dc.citation.issue18pt_BR
dc.citation.spage4446pt_BR
dc.citation.epage4456pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2017.08.007pt_BR
dc.identifier.issn1464-3405pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72110-
dc.description.resumoFluorescent quinone-based BODIPY hybrids were synthesised and characterised by NMR analysis and mass spectrometry. We measured their cytotoxic activity against cancer and normal cell lines, performed mechanistic studies by lipid peroxidation and determination of reduced (GSH) and oxidized (GSSG) glutathione, and imaged their subcellular localisation by confocal microscopy. Cell imaging experiments indicated that nor-β-lapachone-based BODIPY derivatives might preferentially localise in the lysosomes of cancer cells. These results assert the potential of hybrid quinone-BODIPY derivatives as promising prototypes in the search of new potent lapachone antitumor drugs.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBioorganic & Medicinal Chemistry Letterspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectQuinonept_BR
dc.subjectBODIPYpt_BR
dc.subjectLapachonept_BR
dc.subjectCancerpt_BR
dc.subjectSubcellular localizationpt_BR
dc.subject.otherQuinonapt_BR
dc.subject.otherSíntesept_BR
dc.subject.otherCélulas cancerosaspt_BR
dc.subject.otherRessonância magnética nuclearpt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.subject.otherPeroxidaçãopt_BR
dc.subject.otherGlutationapt_BR
dc.subject.otherMicroscopiapt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.titleOn the synthesis of quinone-based BODIPY hybrids: new insights on antitumor activity and mechanism of action in cancer cellspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0960894X17307941pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7038-8560pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8652-7123pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2957-2307pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9379-2817pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0725-8392pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4344-4336pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1281-5453pt_BR
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