Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone

Talita Bárbara Gontijo; Rossimiriam Pereira de Freitas; Guilherme Ferreira de Lima; Lucas Cunha Dias de Rezende; Leandro Ferreira Pedrosa; Thaissa Lúcio Silva; Marilia Oliveira Fonseca Goulart; Bruno Coêlho Cavalcanti; Claudia do Ó Pessoa; Marina Pereira Bruno; José Raimundo Corrêa; Flavio da Silva Emery; Eufrânio Nunes da Silva Júnior

Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/72112

Tipo:	Artigo de Periódico
Título:	Novel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinone
Autor(es):	Talita Bárbara Gontijo Rossimiriam Pereira de Freitas Guilherme Ferreira de Lima Lucas Cunha Dias de Rezende Leandro Ferreira Pedrosa Thaissa Lúcio Silva Marilia Oliveira Fonseca Goulart Bruno Coêlho Cavalcanti Claudia do Ó Pessoa Marina Pereira Bruno José Raimundo Corrêa Flavio da Silva Emery Eufrânio Nunes da Silva Júnior
Resumo:	For the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research.
Assunto:	Quinona Síntese Ressonância magnética nuclear Espectrometria de massa Eletroquímica Agentes antineoplásicos Microscopia Sondas fluorescentes
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	ICX - DEPARTAMENTO DE QUÍMICA
Tipo de Acesso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1039/C6CC07054J
URI:	http://hdl.handle.net/1843/72112
Data do documento:	2016
metadata.dc.url.externa:	https://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc07054j
metadata.dc.relation.ispartof:	Chemical Communications
Aparece nas coleções:	Artigo de Periódico

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