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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/72112
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dc.creatorTalita Bárbara Gontijopt_BR
dc.creatorRossimiriam Pereira de Freitaspt_BR
dc.creatorGuilherme Ferreira de Limapt_BR
dc.creatorLucas Cunha Dias de Rezendept_BR
dc.creatorLeandro Ferreira Pedrosapt_BR
dc.creatorThaissa Lúcio Silvapt_BR
dc.creatorMarilia Oliveira Fonseca Goulartpt_BR
dc.creatorBruno Coêlho Cavalcantipt_BR
dc.creatorClaudia do Ó Pessoapt_BR
dc.creatorMarina Pereira Brunopt_BR
dc.creatorJosé Raimundo Corrêapt_BR
dc.creatorFlavio da Silva Emerypt_BR
dc.creatorEufrânio Nunes da Silva Júniorpt_BR
dc.date.accessioned2024-07-30T18:13:14Z-
dc.date.available2024-07-30T18:13:14Z-
dc.date.issued2016-
dc.citation.volume52pt_BR
dc.citation.issue90pt_BR
dc.citation.spage13281pt_BR
dc.citation.epage13284pt_BR
dc.identifier.doihttps://doi.org/10.1039/C6CC07054Jpt_BR
dc.identifier.issn1364-548Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/72112-
dc.description.resumoFor the first time, a fluorescent lapachone-based BODIPY was synthesised and characterised by NMR and mass spectrometry. Computational and electrochemical aspects, as well as cytotoxic activity and subcellular localisation, were studied. Confocal microscopy experiments indicated that the probe was a specific mitochondria-staining agent. These in-detail analyses were useful in understanding the cytotoxic effects and mechanism of action of this novel hybrid compound. This molecule constitutes a promising prototype owing to its potential biological activities and the new strategies aimed at mechanistic investigations in cells and in vivo, and opens up an interesting avenue of research.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofChemical Communicationspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBODIPYpt_BR
dc.subjectSubcellular localisationpt_BR
dc.subjectQuinonept_BR
dc.subject.otherQuinonapt_BR
dc.subject.otherSíntesept_BR
dc.subject.otherRessonância magnética nuclearpt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.subject.otherEletroquímicapt_BR
dc.subject.otherAgentes antineoplásicospt_BR
dc.subject.otherMicroscopiapt_BR
dc.subject.otherSondas fluorescentespt_BR
dc.titleNovel fluorescent lapachone-based BODIPY: synthesis, computational and electrochemical aspects, and subcellular localisation of a potent antitumour hybrid quinonept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://pubs.rsc.org/en/content/articlelanding/2016/cc/c6cc07054jpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7038-8560pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6974-3724pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0311-3831pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4095-3135pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2957-2307pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6557-8653pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9860-3667pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0725-8392pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4344-4336pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2752-5395pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8652-7123pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1281-5453pt_BR
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