COtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry

Use este identificador para citar ou linkar para este item: http://hdl.handle.net/1843/72115

Tipo:	Artigo de Periódico
Título:	COtab: expedient and safe setup for Pd-catalyzed carbonylation chemistry
Autor(es):	Hugo Paul Collin Wallace Junio Reis Dennis Ulsøe Nielsen Anders Thyboe Lindhardt Marcelo Siqueira Valle Rossimiriam Pereira de Freitas Troels Skrydstrup
Resumo:	Bench-stable tablets (COtabs) have been developed for the rapid and safe production of carbon monoxide. The tablets can be made in less than 5 min without the use of a glovebox and only require a stock solution of an amine base to liberate a specific quantity of CO in a two-chamber system. The COtabs were tested in five different carbonylation reactions and provided similar yields compared to literature procedures. Finally, a gram-scale reaction was conducted, as well as 13C-isotope labeling of the anticancer drug, olaparib.
Assunto:	Catalisadores Compostos de carbono Comportos inorgânicos Óxidos Testes químicos e reagentes Agentes antineoplásicos
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Instituição:	UFMG
Departamento:	ICX - DEPARTAMENTO DE QUÍMICA
Tipo de Acesso:	Acesso Restrito
Identificador DOI:	https://doi.org/10.1021/acs.orglett.9b01423
URI:	http://hdl.handle.net/1843/72115
Data do documento:	2019
metadata.dc.url.externa:	https://pubs.acs.org/doi/10.1021/acs.orglett.9b01423
metadata.dc.relation.ispartof:	Organic Letters
Aparece nas coleções:	Artigo de Periódico

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