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http://hdl.handle.net/1843/72257| Type: | Artigo de Periódico |
| Title: | Synthesis of an uncharged tetra-cyclopeptide acting as a transmembrane carrier: enhanced cellular and nuclear uptake |
| Authors: | Flaviane Francisco Hilário Mohamed Dit Mady Traoré Vincent Zwick Laurence Berry Cláudia Avello Simões Pires Muriel Cuendet Nicolas Fantozzi Rossimiriam Pereira de Freitas Marjorie Maynadier Sharon Wein Henri Vial Yung-Sing Wong |
| Abstract: | A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity. |
| Subject: | Fluorescência Peptídios - Síntese Triazóis Transporte biológico |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1021/acs.orglett.6b03776 |
| URI: | http://hdl.handle.net/1843/72257 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://pubs.acs.org/doi/10.1021/acs.orglett.6b03776 |
| metadata.dc.relation.ispartof: | Organic Letters |
| Appears in Collections: | Artigo de Periódico |
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