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http://hdl.handle.net/1843/72280| Type: | Artigo de Periódico |
| Title: | Influence of COMT Val158Met polymorphism on emotional decision-making: a sex-dependent relationship? |
| Authors: | Danielle de Souza Costa Antoine Bechara Jonas Jardim de Paula Marco Aurélio Romano-Silva Humberto Corrêa da Silva Filho Guilherme Menezes Lage Débora Marques de Miranda Leandro Fernandes Malloy-Diniz |
| Abstract: | The biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the performance on decision-making paradigms. In this study, we investigated the influence of the COMT Val158Met polymorphism on Iowa Gambling Task (IGT) performance depending on sex in a healthy adult sample. Participants were 192 healthy adults (84 men and 108 women). The first 40 choices in the IGT were considered decisions under ambiguity and the last 60 choices decisions under risk. To test our moderation hypothesis we used a separate regressions approach. The results revealed a sex-dependent effect of COMT Va l 158Met polymorphism on decision-making as measured by the IGT. Val/Val women showed the best performance in the last trials of the IGT. Therefore, the COMT Val158Met polymorphism may be considered a genetic marker underlying sex differences in decision-making. |
| Subject: | Neuropsicologia Genética molecular Sexo |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE EDUCAÇÃO FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | 10.1016/j.psychres.2016.10.073 |
| URI: | http://hdl.handle.net/1843/72280 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0165178116300312 |
| metadata.dc.relation.ispartof: | Psychiatry Research |
| Appears in Collections: | Artigo de Periódico |
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