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http://hdl.handle.net/1843/73338| Type: | Artigo de Periódico |
| Title: | Diketopiperazine alkaloids produced by the endophytic fungus Penicillium citrinum and evaluation of their antileishmanial activity |
| Other Titles: | Alcalóides dicetopiperazínicos produzidos pelo endofítico fungo Penicillium citrinum e avaliação de sua atividade antileishmania |
| Authors: | Luiza Guimarães Tunes Vivian Nicolau Gonçalves Daniela Nabak Bueno Carlos Leomar Zani Luiz Henrique Rosa Betania Barros Cota |
| Abstract: | Chromatographic fractionation of the antileishmanial extract obtained from fermentation of the endophytic fungus Penicillium citrinum, isolated from leaves of Ageratum myriadenia, yielded three diketopiperazine alkaloids; cyclo(L-Pro-L-Leu) (1), cyclo-(L-Pro-L-Phe) (2) and tryprostatin B (3). The structures of these compounds were established on the basis of spectroscopic methods and comparison with the literature. Compounds 1 and 2 were active against both amastigote-like forms of Leishmania (Leishmania) amazonensis and intracelular amastigotes of L. (Leishmania) infantum with approximately 50% of parasite growth inhibition at 100 μM. None of the compounds were considered toxic against human leukemia monocyte cell line (THP-1) at 100 μM. It is the first report about isolation of these diketopiperazines from P. citrinum and their antileishmanial potential against L. (L.) infantum. |
| Abstract: | Fracionamento cromatográfico do extrato antileishmania obtido da fermentação do fungo endofítico Penicillium citrinum, isolado de folhas de Ageratum myriadenia, rendeu três alcalóides de dicetopiperazina; ciclo(L-Pro-L-Leu) (1), ciclo-(L-Pro-L-Phe) (2) e triprostatina B (3). O estruturas desses compostos foram estabelecidas com base em métodos espectroscópicos e comparação com a literatura. Os compostos 1 e 2 foram ativos contra ambas as formas de Leishmania (Leishmania) amazonensis e amastigotas intracelulares de L. (Leishmania) infantum com aproximadamente 50% de inibição do crescimento do parasita a 100 μM. Nenhum dos compostos foi considerado tóxico contra a linha celular de monócitos de leucemia humana (THP-1) a 100 μM. É o primeiro relato sobre isolamento dessas dicetopiperazinas de P. citrinum e seu potencial antileishmania contra L. (L.) infantum. |
| Subject: | Microbiologia Fungos Produtos Biológicos Leishmaniose |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| URI: | http://hdl.handle.net/1843/73338 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://academicjournals.org/journal/AJMR/article-full-text-pdf/CB8CF7D62080 |
| metadata.dc.relation.ispartof: | African Journal of Microbiology Research |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Diketopiperazine alkaloids produced.pdfA.pdf | 298.15 kB | Adobe PDF | View/Open |
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