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http://hdl.handle.net/1843/73935| Type: | Artigo de Periódico |
| Title: | Can morphological features evaluated in oral cancer biopsies influence in decision-making? a preliminary study |
| Authors: | Camila Ferreira Leite Karine Duarte da Silva Martinho Campolina Rebello Horta Maria Cássia Ferreira de Aguiar |
| Abstract: | Tumor budding (TB) is a promising prognostic marker in many cancers including oral squamous cell carcinoma. The evaluation of TB in preoperative diagnostic biopsies has been proven be possible; therefore, the association of TB with other morphological features can represent an important aid in the previous treatment decision. This study aims to evaluate TB in oral squamous cell carcinoma (OSCC) biopsies, assessing its association with other morphological characteristics of the sample. A total of 56 cases of OSCC were investigated. In hematoxylin and eosin-stained slides, morphological features including histopathological grading and mode of invasion were evaluated in the deep invasive front. Moreover, immunohistochemistry was performed with anti-multi-cytokeratin antibody helping in the identification of TB, which was graded as low-intensity or no TB and high-intensity TB. Descriptive and bivariate analyses were performed, and the level of significance was set at 5%. The tongue was the most-affected site with 29 (51.7 %) tumors. The predominant mode of invasion (27-48.2 %) was by groups of neoplastic cells without clear boundaries. Of the cases investigated, 37 (66.1 %) were high-intensity TB, which was associated with the mode of invasion of the tumors (p < 0.05). All cases with the worst mode of invasion showed high-intensity TB. Preliminary results showed the potential of morphological features, such as TB and mode of invasion, evaluated in diagnostic specimens of OSCC, aiding in the treatment decision to select patients who could benefit from more-aggressive treatments. |
| Subject: | Immunohistochemistry Mouth Carcinoma, squamous cell Prognosis Biopsy Association Tongue Evaluation study Neoplasms |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.prp.2020.153138 |
| URI: | http://hdl.handle.net/1843/73935 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0344033820319932?via%3Dihub |
| metadata.dc.relation.ispartof: | Pathology Research and Practice |
| Appears in Collections: | Artigo de Periódico |
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