Use este identificador para citar ou linkar para este item:
http://hdl.handle.net/1843/75978| Tipo: | Artigo de Periódico |
| Título: | High CD3+ lymphocytes, low CD66b+ neutrophils, and scarce tumor budding in the invasive front of lip squamous cell carcinomas |
| Autor(es): | Karine Duarte da Silva Patrícia Carlos Caldeira Alessandro Menna Alves Ana Carolina Uchoa Vasconcelos Ana Paula Neutzling Gomes Maria Cássia Ferreira Aguiar Sandra Beatriz Chaves Tarquinio |
| Resumo: | Objective This study aimed to evaluate tumor budding (TB) and quantify the neutrophilic and lymphocytic infiltration in the invasive front of lip squamous cell carcinomas. In addition, the associations between these features and the histopathological grading in the invasive front were analyzed. Design A total of 43 lip squamous cell carcinoma surgical specimens were included and classified in accordance with a histological invasive front grading system. Immunohistochemistry was performed for CD66b and CD3 for the evaluation of neutrophils and T lymphocytes, respectively, in the invasive front of the tumors. Tumor budding was evidenced by AE1/AE3 staining. Results Thirty-six (83.7%) of the tumors were well-differentiated tumors. Eleven (25.6%) of the cases exhibited high-intensity tumor budding. There were low neutrophil and high T lymphocyte infiltrations in the invasive front, leading to a low neutrophil/T lymphocyte ratio in the same region. Moreover, we found an association between tumor budding and the pattern of invasion, and between the CD3+ cell count and the inflammatory infiltrate (p < 0.05). Conclusions The low neutrophil and high T lymphocyte infiltration in the invasive front, and the few high-intensity tumor budding cases are in accordance with the histopathological features of well-differentiated lip tumors. If these characteristics remain in lip squamous cell carcinomas with more aggressive histopathological features, it deserves to be investigated. |
| Assunto: | Carcinoma, squamous cell Lip neoplasms Neutrophils Lymphocytes T-lymphocytes Immunohistochemistry CD3 complex Inflammation |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1016/j.archoralbio.2019.05.027 |
| URI: | http://hdl.handle.net/1843/75978 |
| Data do documento: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0003996919301281 |
| metadata.dc.relation.ispartof: | Archives of Oral Biology |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| High CD3+ lymphocytes, low CD66b+ neutrophils, and scarce tumor budding in the invasive front of lip squamous cell carcinomas.pdf | 643.31 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.