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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/75978
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dc.creatorKarine Duarte da Silvapt_BR
dc.creatorPatrícia Carlos Caldeirapt_BR
dc.creatorAlessandro Menna Alvespt_BR
dc.creatorAna Carolina Uchoa Vasconcelospt_BR
dc.creatorAna Paula Neutzling Gomespt_BR
dc.creatorMaria Cássia Ferreira Aguiarpt_BR
dc.creatorSandra Beatriz Chaves Tarquiniopt_BR
dc.date.accessioned2024-09-05T19:40:12Z-
dc.date.available2024-09-05T19:40:12Z-
dc.date.issued2019-
dc.citation.volume104pt_BR
dc.citation.issueArchives of Oral Biology assunto fao clínica assunto Carcinoma de Células Escamosaspt_BR
dc.citation.spage46pt_BR
dc.citation.epage51pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.archoralbio.2019.05.027pt_BR
dc.identifier.issn1879-1506pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/75978-
dc.description.resumoObjective This study aimed to evaluate tumor budding (TB) and quantify the neutrophilic and lymphocytic infiltration in the invasive front of lip squamous cell carcinomas. In addition, the associations between these features and the histopathological grading in the invasive front were analyzed. Design A total of 43 lip squamous cell carcinoma surgical specimens were included and classified in accordance with a histological invasive front grading system. Immunohistochemistry was performed for CD66b and CD3 for the evaluation of neutrophils and T lymphocytes, respectively, in the invasive front of the tumors. Tumor budding was evidenced by AE1/AE3 staining. Results Thirty-six (83.7%) of the tumors were well-differentiated tumors. Eleven (25.6%) of the cases exhibited high-intensity tumor budding. There were low neutrophil and high T lymphocyte infiltrations in the invasive front, leading to a low neutrophil/T lymphocyte ratio in the same region. Moreover, we found an association between tumor budding and the pattern of invasion, and between the CD3+ cell count and the inflammatory infiltrate (p < 0.05). Conclusions The low neutrophil and high T lymphocyte infiltration in the invasive front, and the few high-intensity tumor budding cases are in accordance with the histopathological features of well-differentiated lip tumors. If these characteristics remain in lip squamous cell carcinomas with more aggressive histopathological features, it deserves to be investigated.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofArchives of Oral Biologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSquamous cell carcinomapt_BR
dc.subject.otherCarcinoma, squamous cellpt_BR
dc.subject.otherLip neoplasmspt_BR
dc.subject.otherNeutrophilspt_BR
dc.subject.otherLymphocytespt_BR
dc.subject.otherT-lymphocytespt_BR
dc.subject.otherImmunohistochemistrypt_BR
dc.subject.otherCD3 complexpt_BR
dc.subject.otherInflammationpt_BR
dc.titleHigh CD3+ lymphocytes, low CD66b+ neutrophils, and scarce tumor budding in the invasive front of lip squamous cell carcinomaspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0003996919301281pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9273-376Xpt_BR
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